标题：女性纤维肌痛患者抑郁症状、睡眠质量及认知特征研究

      作者：刘军军 1，袁心崧 1，庞烨 1，孙乔乔 1，余志波 1，李忠诚 2，张向荣 3，李超蓉 1    1.南京梅山医院医学心理科，江苏 南京 210041；2.南京梅山医院针灸科，江苏 南京 210041；3.南京医科大学附属脑科医院老年精神科，江苏 南京 210041

      卷次： 2020年31卷9期

      【摘要】 目的 探讨女性纤维肌痛患者的抑郁症状、睡眠质量及认知特征。方法 选取2018年3月至2019年3月在南京梅山医院针灸科门诊就诊的109例女性纤维肌痛患者为研究对象(观察组)，并以性别、年龄匹配同时期梅山医院健康体检者50例作为对照组；采用自编问卷收集两组人群的一般人口学资料；采用贝克抑郁量表第2版中文版评估抑郁症状；匹兹堡睡眠质量指数量表评估睡眠质量；Stroop色词测验评估认知功能；比较两受检者上述各项指标的差异。结果 观察组患者的贝克抑郁量表和匹兹堡睡眠质量指数量表评分分别为24.0 (17.0，33.5)分、12.0 (9.0，15.0)分，明显高于对照组的3.0 (0，5.3)分、4.0 (3.0，5.80)分，差异均有统计学意义(P<0.05)；观察组和对照组受试者的 Stroop颜色测验[(65.2±10.1) 分 vs (75.1±10.6)分]、Stroop色-词测验[(37.5±8.8) 分 vs (46.6±8.2) 分]及Stroop色词干扰测验[(28.2±8.9)分 vs (29.4±8.1)分]比较，观察组明显低于对照组，差异均有统计学意义(P<0.05)，但观察组与对照组受试者的 Stroop单词测验[(87.8±15.4)分 vs (88.2±14.2)分]比较差异无统计学意义(P>0.05)；经Pearson相关性分析结果显示，观察组患者的贝克抑郁量表评分与匹兹堡睡眠质量指数量表评分呈正相关(r=0.290，P<0.05)，与Stroop色词干扰测验分呈负相关(r=-1.274，P<0.05)。结论 女性纤维肌痛患者抑郁症状明显，睡眠质量差，认知功能广泛受损，需要加以重点关注。
      【关键词】 女性；纤维肌痛；抑郁症状；睡眠质量；认知功能
      【中图分类号】 R685 【文献标识码】 A 【文章编号】 1003—6350（2020）09—1128—04

Depressive symptoms, sleep quality and cognitive characteristics of female patients with fibromyalgia.
LIUJun-jun 1, YUAN Xin-song 1, PANG Ye 1, SUN Qiao-qiao 1, YU Zhi-bo 1, LI Zhong-cheng 2, ZHANG Xiang-rong 3,LI Chao-rong 1. 1. Department of Medical Psychology, Nanjing Meishan Hospital, Nanjing 210041, Jiangsu, CHINA;2. Department of Acupuncture, Nanjing Meishan Hospital, Nanjing 210041, Jiangsu, CHINA; 3. Department of Psychiatry,Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210041, Jiangsu, CHINA
【Abstract】 Objective To explore the depressive symptoms, sleep status and cognitive characteristics of female pa-tients with fibromyalgia. Methods One hundred and nine female patients with fibromyalgia, who admitted to Departmentof Acupuncture, Nanjing Meishan Hospital from March 2018 to March 2019, were selected as the research object (observa-tion group). Fifty gender and age matched healthy people in Meishan Hospital at the same time were selected as the controlgroup. Their demographic data were collected by self-compiled questionnaire. The depressive symptoms were assessed byChinese version of Beck Depression Inventory-Ⅱ (BDI-Ⅱ), the sleep status was assessed by the Pittsburgh Sleep QualityIndex (PSQI), and the cognitive function was assessed by Stroop Color Word Test. The differences between the two groupswere compared. Results The scores of BDI-Ⅱ and PSQI in the observation group were 24.0 (17.0, 33.5) and 12.0 (9.0,15.0), respectively, which were significantly higher than corresponding 3.0 (0, 5.3) and 4.0 (3.0, 5.80) in the control group(all P<0.05); and the score of Stroop Color Test, Stroop Color-Word Test, Stroop Color-Word Interference Test in the obser-vation group were 65.2±10.1, 37.5±8.8, 28.2±8.9, respectively, which were significantly lower than corresponding 75.1±10.6, 46.6±8.2, 29.4±8.1 in the control group (all P<0.05); The Stroop Word Test scores in the observation group was 87.8±15.4 versus 88.2±14.2 in the control group (P>0.05). Correlation analysis showed that the scores of BDI-Ⅱ were signifi-cant positively correlated with PSQI (r=0.290), but significant negatively correlated with the scores of Stroop Color-WordInterference Test (r=-1.274), all P<0.05. Conclusion Female patients with fibromyalgia have obvious depressive symp-toms, poor sleep quality and extensive impairment of cognitive function, which need to be focused on.
      【Key words】 Female; Fibromyalgia; Depressive symptoms; Sleep quality; Cognitive function