标题：胰岛素在糖尿病性心肌病发病中作用的研究进展

      作者：丘如 1 综述 黄贵心 2 审校    1.广东医科大学研究生学院，广东 湛江 524000；2.广东医科大学附属医院内分泌科，广东 湛江 524000

      卷次： 2020年31卷8期

      【摘要】 糖尿病性心肌病(DCM)为独立于其他主要心血管危险因素的心脏功能障碍，其潜在原因未明，已成为糖尿患者群中心力衰竭的主要原因。其致病因素多样，但主要源于胰岛素抵抗或胰岛素信号传导受损所致的代谢失灵活，以致葡萄糖氧化受损及绝对依赖于脂肪酸供能，对心肌细胞功能产生有害影响。本文综述了糖尿病个体中心脏胰岛素抵抗及胰岛素信号传导受损在DCM发病中的作用进展。
      【关键词】 胰岛素抵抗；胰岛素信号传导受损；糖尿病性心肌病；代谢灵活性
      【中图分类号】 R542.2 【文献标识码】 A 【文章编号】 1003—6350（2020）08—1056—04

Role of insulin in the pathogenesis of diabetic cardiomyopathy.
QIU Ru 1, HUANG Gui-xin 2. 1.Graduate School ofGuangdong Medical University, Zhanjiang 524000, Guangdong, CHINA; 2. Department of Endocrinology, the AffiliatedHospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Diabetic cardiomyopathy (DCM) is a cardiac dysfunction independent of other major cardiovascularrisk factors. Its underlying cause is unknown and has become the main cause of central failure in people with diabetes.The pathogenic factors of DCM are diverse, but it is mainly due to metabolic inflexibility caused by insulin resistance orimpaired insulin signaling, which lead to impaired glucose oxidation and absolute reliance on fatty acid energy, and has adeleterious effect on cardiac muscle cell function. This article reviews the role of cardiac insulin resistance and impairedinsulin signaling in the pathogenesis of DCM in diabetic individuals.
      【Key words】 Insulin resistance; Impaired insulin signaling; Diabetic cardiomyopathy (DCM); Metabolic flexibility·综述·doi:10.3969/j.issn.1003-6350.2020.08.030