标题：miR-206在肿瘤中的作用及机制研究进展

      作者：王傲，简少钦，任鹰孟 综述 肖曼，蔡望伟 审校    海南医学院生物化学与分子生物学教研室，海南 海口 570100

      卷次： 2020年31卷8期

      【摘要】 微小RNA (microRNA，miRNA)是一类由内源基因编码的长度约为 22个核苷酸的非编码单链RNA分子，它们在动植物中参与转录后基因表达调控，其在细胞增殖、分化、凋亡等诸多生理过程中发挥着重要作用。MicroRNA-206 (miR-206)定位于人类第6号染色体上，参与人体中一系列的生物学过程例如细胞增殖、组织器官的生长及肿瘤的发生等。miR-206在肺癌、乳腺癌、胃癌、肝癌及其他肿瘤中发挥抑癌或促癌作用，本文就其在不同肿瘤中的生理活性做一综述。
      【关键词】 微小RNA；miR-206；肿瘤；增殖；调节基因；
      【中图分类号】 R73 【文献标识码】 A 【文章编号】 1003—6350（2020）08—1051—05

Research advances of miR-206 in the development and progression of tumors.
WANG Ao, JIAN Shao-qin, RENYing-meng, XIAO Man, CAI Wang-wei. Department of Biochemistry and Molecular Biology, Hainan Medical University,Haikou 570100, Hainan, CHINA【Abstract】 MicroRNAs (miRNAs) are a kind of non-coding single stranded RNA molecules about 22 nucleo-tides in length encoded by endogenous genes. They participate in the regulation of post transcriptional gene expressionboth in animals and plants, and play an important role in many physiological processes such as cell proliferation, differ-entiation, and apoptosis. MicroRNA-206 (miR-206) is located on human chromosome 6 and takes part in a series of bio-logical processes in the human body as like as cell proliferation, growth of tissues and organs, and tumorigenesis.miR-206 plays a role in suppressing or promoting cell growth in lung cancer, breast cancer, gastric cancer, liver cancerand other tumors. This article reviews its physiological activity in different tumor.
      【Key words】 microRNA; miR-206; Tumor; Proliferation; Regulatory gene·综述·doi:10.3969/j.issn.1003-6350.2020.08.029基金项目：国家自然科学基金(编号：81360359)