标题：肾移植术后腹泻对他克莫司影响的研究进展

      作者：李成 综述 梁国标 审校    遵义医科大学附属医院泌尿外科，贵州 遵义 563000

      卷次： 2020年31卷8期

      【摘要】 腹泻为肾移植术后常见胃肠道并发症，其病因复杂且难以定论。长期腹泻可导致患者脱水、营养吸收不良、排斥反应发生，甚至造成移植物丢失和死亡风险可能。他克莫司(Tacrolimus，FK506)目前常作为临床肾移植术后免疫治疗中的重要免疫抑制药物，其与肾移植术后腹泻发生关系密切。本文就肾移植术后腹泻及其腹泻对他克莫司的影响进行综述。
      【关键词】 肾移植；腹泻；排斥反应；他克莫司；免疫治疗；血药浓度
      【中图分类号】 R699.2 【文献标识码】 A 【文章编号】 1003—6350（2020）08—1038—04

Advances in the study of postoperative diarrhea after renal transplantation and its effect on tacrolimus.
LI Cheng,LIANG Guo-biao. Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA.【Abstract】 Diarrhea is a common gastrointestinal complication after renal transplantation. Its etiology is com-plex and difficult to determine. Long-term diarrhea can lead to dehydration, malnutrition, rejection, and even lead tograft loss and death risk. Tacrolimus (FK506) is often used as the main immunotherapy agent after renal transplantation,which is closely related to postoperative diarrhea. This article reviews diarrhea after renal transplantation and the effectsof diarrhea on tacrolimus.
      【Key words】 Renal transplantation; Diarrhea; Rejection reaction; Tacrolimus (FK506); Immunotherapy; Blooddrug concentration·综述·doi:10.3969/j.issn.1003-6350.2020.08.026基金项目：国家自然科学基金(编号：81460135)；贵州省教育厅创新群体重大研究项目(编号：黔教合KY字[2017]045)