标题：幽门螺旋杆菌的检测方法研究现状

      作者：曾妙，杨三三，李雪诺，陈安海    遵义医科大学附属医院消化内科，贵州 遵义 563003

      卷次： 2020年31卷6期

      【摘要】 幽门螺旋杆菌(Helicobacter pylori，Hp)自 1983年被发现后，被证实与慢性胃炎、消化性溃疡、MALT、胃癌等多种消化道疾病有密切关系。要根除Hp，首先要做到准确的检测Hp。我国人口基数巨大，准确、快捷的检测Hp对大众健康有重要价值。Hp检测方法根据是否需要进行内镜分为侵入性及非侵入性检查。侵入性检查包括内镜检查、快速尿素酶试验、组织病理检查、聚合酶链式反应、细菌培养。非侵入性检查包括尿素呼气试验、15N尿氨排出试验、粪便抗原检测、血清学检查。尽管有多种检测方法，但在流行病学研究中，尚不清楚选择哪一种方法作为诊断Hp感染的金标准。本文综述了检测Hp感染的主要诊断方法，分析了各自的优缺点及相关影响因素，为临床实践及科研工作选取合适的Hp检测方法提供研究依据。
      【关键词】 幽门螺旋杆菌；感染；诊断；检测；影响因素
      【中图分类号】 R378.2 【文献标识码】 A 【文章编号】 1003—6350（2020）06—0784—05

Advances in research of Helicobacter pylori detection methods.
ZENG Miao, YANG San-san, LI Xue-nuo, CHENAn-hai. Department of Gastroenterology, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, CHINA【Abstract】 Since Helicobacter pylori (H. pylori ) was discovered in 1983, it has been confirmed to be closely relat-ed to various gastrointestinal diseases such as chronic gastritis, peptic ulcer, mucosa-associated lymphoid tissue (MALT),and gastric cancer. In order to eradicate H. pylori infection, it is necessary to firstly detect H. pylori infection accurately.China's population is huge, so accurate and rapid detection of H. pylori infection is of great value to public health. H. py-lori infection detection methods are divided into invasive and non-invasive tests based on whether endoscopic examina-tion is required. Invasive tests include endoscopy, rapid urease test, histopathological examination, polymerase chain re-action, and bacteriological culture. Non-invasive tests include a urea breath test (UBT), 15N urinary ammonia excretiontest, stool antigen test, and serological test. Although there are multiple diagnostic methods, it is unclear which method tochoose as the gold standard for detecting H. pylori infection in epidemiological studies. In this work, we review the ad-vantages, disadvantages and their related influencing factors of principal diagnostic methods used to detect H. pylori in-fection, in order to provide research basis for selecting suitable H. pylori detection methods in clinical and scientific re-search.
      【Key words】 Helicobacter pylori (H. pylori); Infection; Diagnosis; Detection; Influencing factors·综述·doi:10.3969/j.issn.1003-6350.2020.06.031