标题：Spexin与肥胖发生的调节机制研究进展

      作者：刘裕晓 综述 1 武革 审校 2    1.广东医科大学研究生学院，广东 湛江 524023；2.广东医科大学附属医院内分泌科，广东 湛江 524000

      卷次： 2020年31卷6期

      【摘要】 Spexin是一种与Galanin/Kisspeptin家族共同进化的新肽。Spexin广泛分布于组织中，并在不同的组织器官中具有多种功能，包括心血管、肾功能及痛觉感受、生殖功能、胃肠道收缩、能量平衡和体重减轻、摄食行为、脂肪酸代谢、葡萄糖稳态，因此，Spexin是一种具有多向性功能的生物学因子。本文主要综述Spexin在能量代谢过程中的摄食行为的调节、脂肪细胞摄取长链脂肪酸、能量利用、代谢等生物学功能。
      【关键词】 Spexin；能量代谢；肥胖；摄食行为；脂肪酸代谢
      【中图分类号】 R151.2 【文献标识码】 A 【文章编号】 1003—6350（2020）06—0777—04

Research progress of the mechanism of spexin affecting the regulation of obesity.
LIU Yu-xiao 1, WU Ge 2. 1.Graduate School, Guangdong Medical University, Zhanjiang 524023, Guangdong, CHINA; 2. Department of Endocrinology,the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Spexin (SPX), as a novel peptide, is coevolved with the Galanin/ Kisspeptin family. Based on the stud-ies in mammals and fish models, SPX has been found to be widely distributed in tissues, and has multiple functions in dif-ferent tissues and organs, including cardiovascular/renal functions, pain perception, reproductive function, gastrointestinaltract contraction, energy balance and weight loss, feeding behavior, fatty acid uptake and glucose homeostasis. This articlemainly reviews the biological functions of spexin, such as the regulation of feeding behavior during the process of energymetabolism, the uptake of long-chain fatty acids by adipocytes, energy utilization, and other biological functions.
      【Key words】 Spexin (SPX); Energetic metabolism; Obesity; Feeding behavior; Fatty acid metabolism·综述·doi:10.3969/j.issn.1003-6350.2020.06.029