标题：IL-34在感染性疾病中的作用研究进展

      作者：赵方方 综述 贺仁忠 审校    遵义医科大学附属医院呼吸内科，贵州 遵义 563003

      卷次： 2020年31卷1期

      【摘要】 白细胞介素-34 (IL-34)是近年来新发现的一种新型的细胞因子，其受体有巨噬细胞集落刺激因子-1受体、蛋白酪氨酸磷酸酶ξ受体以及多配体蛋白聚糖-1。目前，已知 IL-34与集落刺激因子-1的生物学活性相似但不完全相同。研究发现其不仅在各种肿瘤与自身免疫性疾病的发生、发展中发挥重要作用，在细菌、真菌、病毒感染性疾病中也发挥重要作用。因此研究 IL-34的各种感染性疾病的作用机制，有助于为各种感染性疾病治疗提供新的方向。此文就 IL-34的在感染性疾病中的作用做一综述。
      【关键词】 白细胞介素-34；感染性疾病；机制；受体；细胞因子
      【中图分类号】 R63 【文献标识码】 A 【文章编号】 1003—6350（2020）01—0102—04

Advances in the role of IL-34 in infectious diseases.
ZHAO Fang-fang, HE Ren-zhong. Department of RespiratoryMedicine, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, CHINA【Abstract】 Interleukin 34 (IL-34) is a novel cytokine that was identified in recent years, and its receptors in-clude macrophage colony stimulating factor 1 receptor, receptor-like protein-tyrosine phosphatase (RPTP-ξ) and synde-can-1. At present, it is known that IL-34 and colony stimulating factor 1 have similar but not identical biological activi-ties and play an important role in the occurrence and development of various tumors and autoimmune diseases. In addi-tion, it has been found that IL-34 also plays a role in bacterial, fungal and viral infectious diseases. Therefore, studying themechanism of IL-34 in various infectious diseases is conducive to providing new directions for the diagnosis and treat-ment of various infectious diseases. This article reviews the biological activity of IL-34 and its role in infectious diseases.
      【Key words】 Interleukin-34 (IL-34); Infectious disease; Mechanism; Receptor; Cytokine·综述·doi:10.3969/j.issn.1003-6350.2020.01.030基金项目：贵州省科技计划项目(编号：黔科合支撑[2019]2804号)