标题：中国热带地区癫痫病因学调查分析：一项基于医院的研究

      作者：李其富，陈永敏，于利利，靳洲，马琳，王淑荣，陈志斌，廖小平
    (海南医学院附属医院神经内科，海南 海口 570102)

      卷次： 2016年27卷17期

      【摘要】 目的 了解中国热带地区(海南岛)癫痫的病因构成。方法 回顾性纳入2007年1月至2015年12月
在海南医学院附属医院确诊为癫痫的839例患者。收集患者人口学特征、现病史、症状、脑电图(EEG)、脑部核磁共
振(MRI)或CT等影像资料、脑脊液检查、血液检查、既往手术史和家族史。采用国际抗癫痫联盟(ILAE) 2010年修
订的癫痫术语进行癫痫的病因分类。结果 839例癫痫患者发病年龄5周~92岁，平均(35±25.19岁)；男性518例，
女性321例(男:女=1.61:1.00)，其中遗传性癫痫占8.34%，结构-代谢异常性癫痫占66.63% (其中脑卒中21.22%，脑外
伤10.40%，颅内感染8.82%，肿瘤8.70%，皮质发育异常7.51%)，原因不明性癫痫占25.03%。结论 中国热带地区
(海南岛)癫痫患者以结构-代谢性病变为主要病因，癫痫临床诊断中尚需加强病因筛查；ILAE新的病因分类有利于
指导医师进行癫痫临床诊断。

      【关键词】 癫痫；病因；国际抗癫痫联盟；热带地区

      【中图分类号】 R195.4 【文献标识码】 D 【文章编号】 1003—6350（2016）17—2883—03


Etiology of epilepsy in the tropical area of China: a study based on hospital.
LI Qi-fu, CHEN Yong-min, YU Li-li,
JIN Zhou, MA Lin, WANG Shu-rong, CHEN Zhi-bin, LIAO Xiao-ping. Department of Neurology, the Affiliated Hospital of
Hainan Medical University, Haikou 570102, Hainan, CHINA

【Abstract】 Objective To investigate the primary causes of epilepsy in the tropical region of China (Hainan Is-
land). Methods A total of 839 patients with epilepsy in the Affiliated Hospital of Hainan Medical University from Jan.
2007 to Dec. 2015 were enrolled in the study. The clinical data of patients were collected, including demographic charac-
teristics, present illness, semiology, EEG, cerebral CT or MRI, cerebrospinal fluid examination, blood tests, surgical and
family history. Etiologies of epilepsy were categorized as the revised terminology suggested by the International League
Against Epilepsy (ILAE) in 2010. Results The 839 patients were 5 weeks to 92 years old, with the median of 35 years,
including 518 males and 321 females, with the sex ratio of 1.61：1.00. There were 8.34% of genetic epilepsies, 66.63%
of structural-metabolic epilepsies (stroke 21.22%, trauma 10.40%, infection 8.82%, tumor 8.70%, malformations of corti-
·调查研究·
6350.2016.17.047