标题：益气养阴汤治疗妊娠期高血压的疗效及对患者血清学指标的影响

      作者：程贤英，袁梅，刘红    安康市中医医院妇产科，陕西 安康 725000

      卷次： 2019年30卷23期

      【摘要】 目的 探讨益气养阴汤治疗妊娠期高血压的疗效及对患者血清学指标的影响。方法 选取2017年10月至2018年10月期间安康市中医医院妇产科接受治疗的妊娠期高血压患者86例作为研究对象，采用随机数表法将患者分为观察组和对照组，每组43例。对照组患者实施常规治疗方法，观察组在接受常规治疗的基础上给予益气养阴汤治疗。在治疗2个疗程(即6周)后比较两组患者的治疗效果、治疗前后血清学指标的变化及妊娠结局。结果 观察组患者的治疗总有效率为90.70%，明显高于对照组的72.09%，差异有统计学意义(P<0.05)；治疗后观察组患者的尿蛋白水平、收缩压及舒张压分别为(0.20±0.23) g/24 h、(126.23±14.86) mmHg、(80.68±8.98) mmHg，明显低于对照组的(0.42±0.23) g/24 h、(140.39±15.47) mmHg、(92.31±9.54) mmHg，差异均有统计学意义(P<0.05)；治疗后观察组患者的胎心异常、新生儿窒息、剖宫产及产后出血指标的发生率明显低于对照组，差异均有统计学意义(P<0.05)；治疗后，观察组和对照组患者的超氧化物歧化酶(SOD)[ (128.52±23.95) IU/mL vs (107.63±22.84) IU/mL]、谷胱甘肽过氧化物酶(GSH-PX)[(0.43±0.14) μg/L vs (0.35±0.11) μg/L]及血清总抗氧化能力(T-AOC)[(12.08±2.22) U/mL vs(9.78±1.73) U/mL]水平比较，观察组明显高于对照组，而同型半胱氨酸(Hcy)[(4.44±1.28) μmol/L vs (6.27±2.04) μmol/L]、丙二醛(MAD)[(22.98±2.40) μmol/L vs (27.99±2.65) μmol/L]水平比较，观察组明显低于对照组，差异均有统计学意义(P<0.05)。结论 益气养阴汤治疗妊娠期高血压患者有利于降低妊娠不良结局发生的概率及改善血清学指标，临床治疗效果较好。
      【关键词】 益气养阴汤；妊娠期高血压；治疗效果；血清学指标；妊娠结局
      【中图分类号】 R714.24+6 【文献标识码】 A 【文章编号】 1003—6350（2019）23—3034—04

Effect of Yiqi Yangyin Decoction on hypertensive disorders in pregnancy and its effect on serum indexes.
CHENGXian-ying, YUAN Mei, LIU Hong. Department of Obstetrics and Gynecology, Ankang Traditional Chinese Medicine Hospital,Ankang 725000, Shaanxi, CHINA
【Abstract】 Objective To investigate the efficacy of Yiqi Yangyin Decoction in the treatment of hypertensivedisorders in pregnancy and its effect on serum indexes. Methods A total of 86 pregnant hypertensive patients, who ad-mitted to Department of Obstetrics and Gynecology, Ankang Traditional Chinese Medicine Hospital from October 2017to October 2018, were enrolled and divided into the observation group and control group according random number tablemethod, with 43 patients in each group. The patients in the control group were treated with conventional treatment, andthose in the observation group were given Yiqi Yangyin Decoction on the basis of routine treatment. After 2 courses of treat-ment (6 weeks), the treatment effect of the two groups of patients, changes in serum indicators before and after treatmentand pregnancy outcome were compared. Results The total effective rate of the observation group was 90.70%, whichwas significantly higher than 72.09% of the control group (P<0.05). The urinary protein level, systolic blood pressure anddiastolic blood pressure of the observation group were (0.20±0.23) g/24 h, (126.23±14.86) mmHg, (80.68±8.98) mmHg,respectively, which were significantly lower than corresponding (0.42±0.23) g/24 h, (140.39±15.47) mmHg, (92.31±9.54) mmHg of the control group (all P<0.05). After the treatment, the incidence of fetal heart abnormalities, neonatal as-phyxia, cesarean section and postpartum hemorrhage in the observation group were significantly lower than those in thecontrol group (all P<0.05); superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), serum total antioxidant ca-pacity (T-AOC) in the observation group were (128.52±23.95) IU/mL, (0.43±0.14) μg/L, (12.08±2.22) U/mL, respec-tively, which were significantly higher than corresponding (107.63±22.84) IU/mL, (0.35±0.11) μg/L, (9.78±1.73) U/mLin the control group; while homocysteine (Hcy) and malondialdehyde (MAD) were (4.44±1.28) μmol/L and (22.98±2.40) μmol/L, which were significantly lower than (6.27±2.04) μmol/L and (27.99±2.65) μmol/L in the control group (allP<0.05). Conclusion For hypertensive patients in pregnancy, Yiqi Yangyin Decoction is beneficial to reduce the probabil-ity of adverse pregnancy outcomes and improve serum markers, and its clinical treatment effect is better.
      【Key words】 Yiqi Yangyin Decoction; Hypertensive disorders in pregnancy; Treatment effect; Serological indica-tors; Pregnancy outcome