标题：丙种球蛋白对手足口病患儿血清炎症细胞因子水平的影响

      作者：司马贯忠，邓见玲，郭承勇    深圳市宝安区中心医院儿科，广东 深圳 518102

      卷次： 2019年30卷22期

      【摘要】 目的 探讨丙种球蛋白(IVIG)对手足口病(HFMD)患儿血清炎症细胞因子水平的影响。方法 将深圳市宝安区中心医院儿科2018年1~12月收治的78例手足口病患儿以随机数表法分为常规治疗组和 IVIG组，每组39例，常规治疗组患儿给予常规治疗，IVIG组患儿在常规治疗的基础上联合 IVIG治疗，同时选取40例健康体检儿童作为对照组，比较三组儿童的血清炎性细胞因子水平，并比较治疗前后患儿炎性细胞因子变化情况。结果 治疗前常规治疗组患儿的肿瘤坏死因子α (TNF-α)、白细胞介素-6 (IL-6)和C反应蛋白(CRP)水平分别为(4.28±2.03) μg/L、(5.69±3.04) mg/L、(4.33±1.52) μg/L，IVIG组分别为(4.31±2.10) μg/L、(5.71±3.07) mg/L、(4.31±1.48) μg/L，对照组分别为(1.06±0.59) μg/L、(2.41±0.27) mg/L、(1.19±0.51) μg/L，常规治疗组和 IVIG组患儿的上述各项指标明显高于对照组，差异均有统计学意义(P<0.05)；治疗前常规治疗组和 IVIG组患儿血清中TNF-α、IL-6和CRP水平比较差异均无统计学意义(P>0.05)；治疗后 IVIG组患儿的TNF-α、IL-6和CRP水平分别为(1.01±0.48) μg/L、(2.40±0.69) mg/L、(1.21±0.50) μg/L，明显低于常规治疗组的(1.24±0.51) μg/L、(2.81±0.72) mg/L、(1.58±0.53) μg/L，差异均有统计学意义(P<0.05)。结论 IVIG可有效降低手足口病患儿血清中炎症细胞因子水平，从而达到对抗炎症反应和调节免疫功能的作用，促进患儿康复。
      【关键词】 手足口病；丙种球蛋白；细胞因子；影响；临床意义
      【中图分类号】 R725.9 【文献标识码】 A 【文章编号】 1003—6350（2019）22—2966—03

Effects of immunoglobulin on serum levels of inflammatory cytokines in children patients with hand, foot andmouth disease.
SIMA Guan-zhong, DENG Jian-ling, GUO Cheng-yong. Shenzhen Baoan District Central Hospital,Shenzhen 518102, Guangdong, CHINA
【Abstract】 Objective To investigate the effects of immunoglobulin (IVIG) on serum level of inflammatory cy-tokines in children patients with hand, foot and mouth disease (HFMD). Methods The clinical data of 78 children withHFMD in Shenzhen Baoan District Central Hospital from January 2018 to December 2018 were retrospectively ana-lyzed. The patients were assigned to receive either conventional treatment (conventional treatment group) or IVIG basedon conventional treatment (IVIG group). At the same time, 40 children undergoing the healthy physical examinationwere selected as the control group. The changes of inflammatory factor levels were compared between the two groups be-·短篇论著·doi:10.3969/j.issn.1003-6350.2019.22.033