标题：清心消瘤汤联合米非司酮对子宫肌瘤患者疾病控制和血清Bax、Bcl-2水平的影响

      作者：惠雪莲，舒瑾，董鹂芸，赵娟    西安市中医医院妇科，陕西 西安 710021

      卷次： 2019年30卷22期

      【摘要】 目的 探究清心消瘤汤联合米非司酮对子宫肌瘤患者疾病控制和血清小鼠来源抗体(Bax)、B淋巴细胞瘤-2 (Bcl-2)水平的影响。方法 选取2016年8月至2018年12月西安市中医医院妇科收治的子宫肌瘤患者108例，按随机单双编号分为观察组与对照组各54例，对照组采用米非司酮治疗，观察组采用清心消瘤汤联合米非司酮治疗，两组均治疗3个月，比较两组患者治疗后的疾病控制情况、血清Bax、Bcl-2水平、血红蛋白(HB)水平及子宫肌瘤体积、子宫体积、不良反应发生情况。结果 观察组患者的控制总有效率为88.89%，明显高于对照组的72.22%，差异有统计学意义(P<0.05)；治疗后，观察组患者的血清Bax水平为(4.04±0.59) ng/mL，明显高于对照组的(3.27±0.48) ng/mL，血清Bcl-2水平为(1.21±0.24) ng/mL，明显低于对照组的(1.68±0.26) ng/mL，差异均有统计学意义(P<0.05)；治疗后，观察组患者的HB水平为(127.44±8.29) g/L，明显高于对照组的(106.73±9.38) g/L，差异有统计学意义(P<0.05)；治疗后，观察组患者的子宫肌瘤体积与子宫体积分别为(35.56±7.46) cm3、(100.25±9.33) cm3，明显小于对照组的(45.87±9.08) cm3、(119.43±11.18) cm3，差异均有统计学意义(P<0.05)；观察组和对照组患者的不良反应发生率分别为3.70%(2/54)、7.41%(4/54)，差异无统计学意义(P>0.05)。结论 清心消瘤汤联合米非司酮能提高子宫肌瘤控制效果，上调血清Bax水平，减小子宫体积及肌瘤体积，缓解贫血，且安全性高。
      【关键词】 清心消瘤汤；米非司酮；子宫肌瘤；Bax；体积
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2019）22—2928—04

Effects of Qingxin Xiaoliu Decoction and mifepristone on disease control, serum Bax and Bcl-2 level in patientswith hysteromyoma.
HUI Xue-lian, SHU Jin, DONG Li-yun, ZHAO Juan. Department of Gynecology, Xi'an TraditionalChinese Medicine Hospital, Xi'an 710021, Shaanxi, CHINA
【Abstract】 Objective To explore the effects of Qingxin Xiaoliu Decoction combined with mifepristone on dis-ease control, serum Bax level, B-cell lymphoma 2 (BCL-2) in patients with hysteromyoma. Methods A total of 108 pa-tients with hysteromyoma admitted to Xi'an Traditional Chinese Medicine Hospital from August 2016 to December 2018were randomly divided into observation group and control group according to the odd and even number of admissionnumber, with 54 patients in each group. The control group was treated with mifepristone, and the observation group wastreated with Qingxin Xiaoliu Decoction combined with mifepristone, both for three months. The disease control, serumBax, Bcl-2, hemoglobin (HB), volume of hysteromyoma, uterine volume, and adverse reactions were compared betweenthe two groups after treatment. Results The total effective rate of the observation group was 88.89%, which was signifi-