标题：Graves病的遗传异质性研究进展

      作者：刘裕晓 1，武革 2    1.广东医科大学研究生学院，广东 湛江 524023；2.广东医科大学附属医院内分泌科，广东 湛江 524001

      卷次： 2019年30卷21期

      【摘要】 Graves病是一种累积多系统的自身免疫性甲状腺疾病，临床资料提示，易感基因和环境因素相互作用是疾病发生的关键因素，其中遗传因素在本病的发生、发展过程中起着重要的作用。尽管已进行了大量的研究，Graves病的遗传学机制至今尚未阐明，但具有明显的遗传异质性特点。本文就Graves病常见的免疫调节基因及甲状腺特异基因的遗传异质性特征做一综述。
      【关键词】 Graves病；遗传异质性；单核苷酸多态性；免疫调节基因；甲状腺特异基因
      【中图分类号】 R581.1 【文献标识码】 A 【文章编号】 1003—6350（2019）21—2817—04

Genetic heterogeneity of Graves' disease.
LIU Yu-xiao 1, WU Ge 2. 1.Graduate School, Guangdong Medical University,Zhanjiang 524023, Guangdong, CHINA; 2. Department of Endocrinology, the Affiliated Hospital of Guangdong MedicalUniversity, Zhanjiang 524001, Guangdong, CHINA【Abstract】 Graves' disease is a cumulative multi-system autoimmune thyroid disease. Clinical data suggest thatthe interaction between susceptible genes and environmental factors is the key factor of disease occurrence, in which ge-netic factors play an important role in the occurrence and development of this disease. Although many studies have beencarried out, the genetic mechanism of Graves' disease has not yet been clarified, but it is clearly characterized by obviousgenetic heterogeneity. In this paper, the genetic heterogeneity of immunomodulatory genes and thyroid-specific genes inGraves's disease is reviewed.
      【Key words】 Graves' disease; Genetic heterogeneity; Single nucleotide polymorphism (SNP); Immunoregulatorygene; Thyroid-specific gene·综述·doi:10.3969/j.issn.1003-6350.2019.21.029基金项目：广东省自然科学基金(编号：06028968)