标题：促红细胞生成素对脑损伤早产儿智力发育水平与受损神经细胞及听觉神经通路的影响

      作者：许柯 1，孟浩 2，杨云成 1，边静 1，刑立群 1，孙明 1    汉中市中心医院新生儿科 1、急诊科 2，陕西 汉中 723000

      卷次： 2019年30卷21期

      【摘要】 目的 探讨促红细胞生成素对脑损伤早产儿智力发育水平与受损神经细胞及听觉神经通路的影响。方法 选取2015年6月至2018年6月期间汉中市中心医院收治的脑损伤早产儿98例，按照随机数表法分为观察组和对照组各49例，对照组给予常规治疗，观察组在常规治疗基础上加用促红细胞生成素治疗，连续治疗4周。比较两组患儿治疗前后的智力发育指数(MDI)、心理运动发育指数(PDI)、新生儿行为神经测定(NBNA)评分、血清神经元特异性烯醇化酶(NSE)、S-100β、白细胞介素-6 (IL-6)、脑干听觉诱发电位(BAEP)各波峰潜伏期、峰间期水平的差异，记录出院后 6个月内两组患儿的不良反应发生率。结果 治疗前，两组患儿的MDI、PDI、NBNA评分、NSE、S-100β、IL-6水平等指标比较，差异均无统计学意义(P>0.05)；治疗后，两组患儿的MDI、PDI、NBNA评分较治疗前明显升高，NSE、S-100β、IL-6水平明显降低，BAEPⅠ、Ⅲ、Ⅴ及Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ期间值较治疗前明显缩短，且治疗后，观察组患儿的以上指标改善情况明显优于对照组，差异均有统计学意义(P<0.05)；观察组患儿的并发症发生率为4.08%，明显低于对照组的14.29%，差异有统计学意义(P<0.05)。结论 促红细胞生成素能显著提高脑损伤早产儿的智力发育水平，有效保护受损的神经细胞，修复受损的听觉神经通路，降低炎性因子生成，改善脑部损伤，值得临床推广应用。
      【关键词】 促红细胞生成素；脑损伤；早产儿；智力发育；神经细胞；听觉神经通路
      【中图分类号】 R722 【文献标识码】 A 【文章编号】 1003—6350（2019）21—2788—04

Effect of erythropoietin on mental development and damaged nerve cells and auditory nerve pathway in prematureinfants with brain injury.
XU Ke 1, MENG Hao 2, YANG Yun-cheng 1, BIAN Jing 1, XING Li-qun 1, SUN Ming 1. Departmentof Neonatology 1, Emergency Department 2, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi, CHINA
【Abstract】 Objective To investigate the effects of erythropoietin on mental development and damaged nervecells and auditory nerve pathways in premature infants with brain injury. Methods Ninety-eight premature infants withbrain injury admitted to Hanzhong Central Hospital from June 2015 to June 2018 were selected. According to the ran-dom number table method, the patients were divided into observation group and control group, with 49 patients in eachgroup. The control group received routine treatment, and the observation group applied erythropoietin continuously for 4weeks on the basis of routine treatment. The mental development index (MDI), psychomotor development index (PDI),neonatal behavioral neurological (NBNA) score, serum neuron specific enolase (NSE), S-100β, and white blood cellswere compared between the two groups before and after treatment. Interleukin-6 (IL-6), brainstem auditory evoked po-tential (BAEP) peak latency, peak interstage levels, and the incidence of adverse reactions within 6 months after dis-charge were compared between the two groups. Results Before treatment, there were no significant differences in