标题：免疫因素在银屑病发病机制中的研究进展

      作者：李华润 1，2，温炬 2，秦思 2，马静 2，郑荣昌 2，李婷 2，冯洁莹 2，袁绍萍 1,2，郑晓欢 1，2，黄锦萍 2，周玉婵 2    1.南方医科大学第二临床医学院，广东 广州 510280；2.广东省第二人民医院皮肤性病科，广东 广州 510317

      卷次： 2019年30卷19期

      【摘要】 银屑病是一种常见并易复发的慢性炎症性皮肤病，以青壮年为多，对患者的身体健康及精神影响甚大。目前，大量证据支持银屑病的发生是多因素的共同作用的结果，包括免疫因素、遗传因素、感染因素、环境因素等。其中，免疫因素在银屑病发病机制中起重要作用，尤其是淋巴T细胞的核心作用，本文通过分别综述其主要涉及的免疫细胞、免疫分子、免疫相关通路在银屑病发病机制的作用及研究进展，阐明其临床意义，对银屑病的靶点治疗探索新思路，进而为临床的实践提供进一步的指导。
      【关键词】 银屑病；免疫因素；发病机制；研究进展；靶点治疗；新思路
      【中图分类号】 R758.63 【文献标识码】 A 【文章编号】 1003—6350（2019）19—2561—05

Research progress of immune factors in the pathogenesis of psoriasis.
LI Hua-run 1,2, WEN Ju 2, QIN Si 2, MA Jing 2,ZHENG Rong-chang 2, LI Ting 2, FENG Jie-ying 2, YUAN Shao-ping 1,2, ZHENG Xiao-huan 1,2, HUANG Jin-ping 2, ZHOUYu-chan 2. 1.The Second Clinical Medical School (Zhujiang Hospital), Southern Medical University, Guangzhou 510280,Guangdong, CHINA; 2. Department of Dermatology & STD, Guangdong No.2 Provincial People’s Hospital, Guangzhou510317, Guangdong, CHINA【Abstract】 Psoriasis is a chronic inflammatory skin disease which is common and easy to relapse. It happensmostly in young adults and has a great impact on the physical health and mental health of patients. At present, plentyof evidence supports that the occurrence of psoriasis is the result of multiple factors, including immune factors, genet-ic factors, infectious factors, environmental factors. Among them, immune factors especially T-lymphocyte play an im-portant role in the pathogenesis of psoriasis. Through separately reviewing the role of immune cells, immune mole-cules and immune related pathways in the pathogenesis of psoriasis and their research progress, this thesis clarifiestheir clinical significance, explores new ideas for the targeted therapy of psoriasis, and provides further guidance forclinical practice.
      【Key words】 Psoriasis; Immune factors; Pathogenesis; Research progress; Targeted therapy; New ideas·综述·doi:10.3969/j.issn.1003-6350.2019.19.033基金项目：广东省中医药局科研项目(编号：20181011)