标题：糖尿病足与T淋巴细胞亚群的相关性研究

      作者：李晓春 1，吴建能 1，张华珍 2，邹艳芳 1
    (1.韶关粤北人民医院内分泌科，广东 韶关 512000；
2.翁源县妇幼保健院，广东 韶关 512600）

      卷次： 2013年24卷11期

      【摘要】 目的 对比T淋巴细胞亚群在糖尿病足感染及非感染患者中的差异，研究T淋巴细胞与糖尿病足
感染的关系。方法 选取我院收治的84例糖尿病足患者，按照感染与否分为感染组(48例)与非感染组(36例)，
比较感染组与非感染组患者入院时及观察终点时T淋巴细胞亚群(CD3+细胞、CD4+细胞、CD8+细胞、CD4+/CD8+比
值)的差异。结果 入院时糖尿病足感染组的CD3+细胞[(59.34±4.45)%]、CD4+细胞[(32.54±3.54)%]及CD4+/CD8+细
胞(1.25±0.40)比例均低于非感染组，而CD8+细胞[(27.57±4.53)%]则高于非感染组[(24.55±3.60)%]。感染组在观察
终点时的CD3+细胞[(63.23±5.54)%]、CD4+细胞[(35.64±3.13)%]及CD4+/CD8+细胞比例(1.40±0.25)均高于入院时水
平，但CD8+细胞[(25.49±4.03)%]低于入院时水平，其差异均具有统计学意义（P<0.05）。结论 糖尿病足并发感染
的患者中存在T淋巴细胞亚群的变化，提示糖尿病足感染患者存在细胞免疫功能的缺陷。

      【关键词】 T淋巴细胞；糖尿病足；感染

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2013）11—1628—03


Correlation between T lymphocyte subsets and diabetic foot infection.
LI Xiao-chun 1, WU Jian-neng 1, ZHANG
Hua-zhen 2, ZOU Yan-fang 1. 1. Department of Endocrinology, Guangdong Shaoguan Yuebei People's Hospital,
Shaoguan 512000, Guangdong, CHINA; 2. Wengyuan Maternal and Child Health Hospital, Shaoguan 512600,
Guangdong, CHINA

【Abstract】 Objective To compare the differences of T lymphocyte subsets in diabetic foot infection and non-in-
fected patients, and to study the relationship of T lymphocytes with diabetic foot infection. Methods Eighty-four patients
with diabetic foot were collected and divided into infected group (48 cases) and non-infected group (36 patients) according
to the infection. The T-lymphocyte subsets (CD3+ cells, CD4+ cells, CD8+ cells, CD4+/CD8+ ratio) were compared between
infected group and non-infected group at admission and the end of observation. Results The CD3 + cells [(59.34±
4.45%)], CD4+ cells [(32.54±3.54%)] and CD4+/CD8+ ratio [(1.25±0.40)] in infected group were significnatly lower than
those in non-infected group at admission, whereas CD8+ cells [(27.57±4.53)%] in infected group was significantly high-
·论 著·doi:10.3969/j.issn.1003-6350.2013.11.0679