标题：DRP1表达与恶性肿瘤患者预后关系的Meta分析

      作者：吕佳乐，朱云娜，王雅，梁路，李宁    山西医科大学第一医院病理科，山西 太原 030001

      卷次： 2021年32卷17期

      【摘要】 目的 系统评价动力相关蛋白1 (DRP1)的表达对肿瘤患者预后的评估价值，以期为肿瘤患者预测预后和治疗提供新的靶点。方法 计算机检索PubMed、EMBASE、Web of Science、CNKI及万方等数据库，检索时间为建库至2020年10月，按照文献纳入与排除标准筛选文献并提取数据，根据Newcastle-Ottawa Scale (NOS)量表评估文献质量，采用Review Maneger5.3软件进行Meta分析。结果 共纳入10篇研究共1 138例患者。Meta分析结果显示DRP1高表达与肿瘤患者OS有关(HR=1.46，95%CI为1.11~1.92，P<0.001)。亚组分析结果显示，DRP1高表达与消化系统恶性肿瘤患者OS相关(HR=1.61，95%CI为1.12~2.31，P<0.001)，与肿瘤患者淋巴结转移发生率相关(OR=3.24，95%CI为1.85~5.67，P<0.001)。结论 DRP1高表达的肿瘤患者预后较差，且与淋巴结转移发生相关，可以作为肿瘤预测预后及治疗的新靶点。
      【关键词】 动力相关蛋白1；恶性肿瘤；消化系统肿瘤；预后；淋巴结转移；Meta分析
      【中图分类号】 R730.7 【文献标识码】 A 【文章编号】 1003—6350（2021）17—2278—06

Meta-analysis of the relationship between DRP1 expression and prognosis in patients with malignant tumor.
LVJia-le, ZHU Yun-na, WANG Ya, LIANG Lu, LI Ning. Department of Pathology, the First Clinical Medical College of ShanxiMedical University, Taiyuan 030001, Shanxi, CHINA
【Abstract】 Objective To systematically evaluate the prognostic value of dynamic related protein 1(DRP1) expression in cancer patients, so as to provide a new target for prediction and treatment of cancer patients.Methods PubMed, Embase, Web of Science, CNKI, Wanfang and other databases were searched by computer frominception to October 2020. The literatures were screened according to the inclusion and exclusion criteria, and extract-ed. Literature quality was evaluated according to the Newcastle-Ottawa Scale (NOS), and Review Manager software(Version 5.3) was used for analysis. Results A total of 1 138 patients from 10 studies were included in the analysis.Meta analysis showed that high expression of DRP1 was associated with OS (HR=1.46, 95%CI: 1.11-1.92, P<0.001).Subgroup analysis showed that high expression of DRP1 was associated with OS (HR=1.61, 95%CI: 1.12-2.31, P<0.001) and lymph node metastasis (OR=3.24, 95% CI: 1.85-5.67, P<0.001) in patients with gastrointestinal cancer.Conclusion Patients with high expression of DRP1 have poor prognosis and are associated with lymph node metasta-sis, which can be used as a new target for cancer prognosis and treatment.
      【Key words】 Dynamin related protein 1 (DRP1); Malignant tumor; Digestive system neoplasm; Prognosis;Lymph node metastasis; Meta-analysis·荟萃分析·doi:10.3969/j.issn.1003-6350.2021.17.027