标题：多囊卵巢综合征患者血清抗苗勒氏激素与代谢综合征的关系

      作者：姚守润 1，崔海斌 1，孔令丹 2    1.武警陕西省总队医院卫勤处，陕西 西安 710054；2.北京市第六医院妇产科，北京 100010

      卷次： 2020年31卷16期

      【摘要】 目的 探讨多囊卵巢综合征(PCOS)患者血清抗苗勒氏激素(AMH)与代谢综合征(MS)的关系。方法 回顾性分析武警陕西省总队医院 2017年 2月至 2019年 2月就诊的 110例 PCOS患者的临床资料，比较合并MS组(n=57)与未合并MS组(n=53)患者各相关指标之间的差异，并分析AMH水平与相关指标之间的关系。结果 合并MS组与未合并MS组患者的体质量指数 (BMI)、腰臀围比 (WHR)、收缩压 (SBP)、舒张压(DBP)、空腹血糖(FBG)、胰岛素(INS)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、抗苗勒氏激素(AMH)水平比较，差异均具有统计学意义(P<0.05)；血清AMH水平与INS、HOMA-IR、TC、TG呈正相关(P<0.05)；血清AMH水平与BMI、FBG、HDL、VLDL、LDL、载脂蛋白 a (Apo-a)、载脂蛋白b (Apo-b)无相关性(P>0.05)。结论 PCOS患者血清AMH水平与代谢综合征密切相关，可根据PCOS患者血清AMH水平尽早采取干预措施，以降低代谢综合征导致的远期心血管疾病及糖尿病疾病风险。
      【关键词】 多囊卵巢综合征；代谢综合征；血清抗苗勒氏激素；相关性
      【中图分类号】 R711.75 【文献标识码】 A 【文章编号】 1003—6350（2020）16—2079—03

Relationship between serum anti-Mullerian hormone and metabolic syndrome in patients with polycystic ovarysyndrome.
YAO Shou-run 1, CUI Hai-bin 1, KONG Ling-dan 2. 1. Department of Medical Service, Shaanxi ProvincialGeneral Hospital of Armed Police, Xi'an 710054, Shaanxi, CHINA; 2. Department of Obstetrics and Gynecology, BeijingSixth Hospital, Beijing 100010, CHINA
【Abstract】 Objective To discuss the relationship between serum anti-Mullerian hormone (AMH) and metabol-ic syndrome (MS) in patients with polycystic ovary syndrome (PCOS). Methods The clinical data of 110 patients withPCOS, who admitted to Shaanxi Provincial General Hospital of Armed Police from February 2017 to February 2019,were analyzed retrospectively. The differences on the relevant indexes of the combined MS group and the non-combinedMS group and the relationship between AMH level and relevant indexes were analyzed. Results There were statistical-ly significant differences in B body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolicblood pressure(DBP), fasting blood glucose (FBG), insulin (INS), homeostasis model assessment of insulin resistance(HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL),and AMH between the two groups (all P<0.05); serum AMH level was positively correlated with INS, HOMA-IR, TC andTG (all P<0.05); serum AMH level was not positively correlated with BMI, FBG, HDL, very low-density lipoprotein(VLDL), LDL, apolipoprotein (Apo)-A and Apo-B (all P>0.05). Conclusion There is a close relationship between serumAMH level and MS in PCOS patients. Intervention measures can be taken as early as possible according to the serumAMP level of PCOS patients to reduce the risk of cardiovascular disease and diabetes caused by MS in the long term.
      【Key words】 Polycystic ovary syndrome (PCOS); Metabolic syndrome (MS); Serum anti-Mullerian hormone(AMH); Relationship