标题:超声软指标NT与NF检测对胎儿21-三体综合征产前诊断的价值
作者:王文 1,白雪 2,熊静 3 1.安康市疾病预防控制中心卫生科,陕西 安康 725000;2.安康市中心医院超声科,陕西 安康 725000;3.安康市妇幼保健院超声科,陕西 安康 725000
卷次:
2019年30卷14期
【摘要】 目的 探讨超声软指标(USM)颈项透明层(NT)、颈后皮肤皱褶(NF)在产前筛查21-三体综合征中的应用价值。方法 选取2015年7月至2017年8月在安康市妇幼保健院进行产前筛查的3 108例孕早、中期孕妇作为研究对象,通过USM筛查胎儿发生21-三体综合征的情况,以羊膜穿刺及羊水细胞染色体核型分析结果为金标准,通过四格表法计算NT、NF增厚对21-三体胎儿的诊断灵敏度、特异度。结果 3 108例孕妇经USM筛查中有NT阳性者61例(1.96%),NF阳性者53例(1.71%),NT+NF阳性者36例(1.16%);羊水细胞染色体核型分析结果共检出 21-三体综合征 16例,其中,NT阳性者中检出 21-三体综合征 4例(6.56%),NF阳性者检出 21-三体综合征 5例(9.43%);NT+NF阳性者检出 21-三体综合征 7例(19.44%);USM中NT、NF筛查诊断 21-三体综合征的灵敏度为88.89%,特异度为95.66%。结论 USM中NT、NF均可用于产前筛查21-三体,NT+NF均增厚可增加21-三体的发生风险,USM诊断21-三体的特异度及灵敏度均较高。
【关键词】 孕早、中期;颈项透明层;超声软指标;产前诊断;21-三体综合征;颈后皮肤皱褶
【中图分类号】 R714.53 【文献标识码】 A 【文章编号】 1003—6350(2019)14—1833—04
Value of nuchal translucency and nuchal fold in the prenatal diagnosis of fetal trisomy 21 syndrome.
WANG Wen 1,BAI Xue 2, XIONG Jing 3. 1. Department of Health, Ankang Center for Disease Control and Prevention, Ankang 725000,Shaanxi, CHINA; 2. Department of Ultrasound, Ankang Central Hospital, Ankang 725000, Shaanxi, CHINA; 3. Departmentof Ultrasound, Maternal and Child Health Hospital of Ankang City, Ankang 725000, Shaanxi, CHINA
【Abstract】 Objective To evaluate the value of the ultrasound markers (USM) of nuchal translucency (NT) andnuchal fold (NF) for screening 21-trisomy syndrome (Down's syndrome). Methods A total of 3 108 pregnant women,who were screened in Department of Health of Ankang Center for Disease Control and Prevention from July 2015 to Au-gust 2017, were selected as study subjects. USM screening was used to screen the fetus for 21 trisomy syndrome. The re-sults of amniocentesis and karyotype analysis of amniotic fluid cells were taken as the gold standard. The sensitivity andspecificity of NT, NF thickening in 21-trisomy fetus were calculated by four-grid method. Results Among 3 108 preg-nant women, 61 (1.96%) were NT positive, 53 (1.71%) were NF positive, and 36 (1.16%) were positive for NT and NF.
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