标题：妊娠晚期孕妇维生素A含量与妊娠期高血压疾病和分娩结局的关系

      作者：黄长芳，续靖宁    西北妇女儿童医院产科，陕西 西安 710061

      卷次： 2019年30卷14期

      【摘要】 目的 探讨妊娠晚期孕妇维生素A含量与妊娠期高血压疾病(HDCP)和分娩结局的关系。方法 选择西北妇女儿童医院产科2017年1月至2018年12月期间收治的104例HDCP患者纳入观察组，其中妊娠期高血压40例、轻度子痫前期42例、重度子痫前期22例，选取50例常规在我院产检的健康产妇纳入对照组。对所有受检者进行血清维生素A水平测定，其中观察组患者维生素A降低者59例(A组)，正常者45例(B组)。记录观察组患者的不良妊娠结局发生情况。结果 观察组患者的血清维生素A水平为(0.34±0.10) mg/L，明显低于对照组的(0.43±0.13) mg/L，差异有统计学意义(P<0.05)；观察组患者中，血清维生素A水平均随着病情的加重逐级降低，差异均有统计学意义(P<0.05)；A组患者产后出血、早产、低体质量的发生率分别为 10.17%、13.56%、16.95%，明显高于B组的 2.22%、4.44%、6.67%，差异均有统计学意义(P<0.05)。结论 维生素A与妊娠期高血压疾病的发生、病情进展关系密切，且还与早产、低体质量儿、产后出血等多种不良分娩结局相关。
      【关键词】 妊娠期高血压疾病；维生素A；妊娠结局；子痫前期；关系
      【中图分类号】 R714.24+6 【文献标识码】 A 【文章编号】 1003—6350（2019）14—1816—03

Relationship between vitamin A content in pregnant women at the third trimester of pregnancy and hypertensivedisorder complicating pregnancy and delivery outcome.
HUANG Chang-fang, XU Jing-ning. Department ofObstetrics, Northwest Women and Children's Hospital, Xi'an 710061, Shaanxi, CHINA
【Abstract】 Objective To investigate the relationship between vitamin A in pregnant women at the third trimes-ter of pregnancy and hypertensive disorder complicating pregnancy (HDCP) and delivery outcome. Methods A total of104 HDCP patients treated in Department of Obstetrics, Northwest Women and Children's Hospital from January 2017 toDecember 2018 were selected as the study subjects and included into the observation group, including 40 patients of ges-tational hypertension, 42 patients of mild preeclampsia, and 22 patients of severe preeclampsia. Fifty healthy parturientsundergoing routine obstetric examination were enrolled in the control group. Serum vitamin A levels were measured inall the subjects. In the observation group, 45 HDCP patients with normal vitamin A levels were assigned in to group B and59 patients with insufficient vitamin A levels in to group A. The incidence of adverse pregnancy outcomes in HDCP pa-tients was recorded and compared. Results The serum vitamin A level in the observation group was (0.34±0.10) mg/L,which was significantly lower than (0.43±0.13) mg/L in the control group (P<0.05). In HDCP patients, the serum vita-min A level decreased gradually with the aggravation of the disease, pregnancy hypertension, mild eclampsia and severeeclampsia, with statistically significant difference (P<0.05). The incidence of blood, premature delivery, and low bodyweight in group A was 10.17%, 13.56%, 16.95%, significantly higher than 2.22%, 4.44%, 6.67% in group B (P<0.05).Conclusion Vitamin A is closely related to the occurrence and progression of hypertensive disorder complicating preg-nancy. It is also associated with many adverse childbirth outcomes, such as premature delivery, low birth weight infants,and postpartum hemorrhage.
      【Key words】 Hypertensive disorder complicating pregnancy; Vitamin A; Pregnancy outcome; Preeclampsia; Re-lationship