标题：免疫异常流产机制研究进展

      作者：翟志成 综述 孙文霞 审校    长治医学院妇产科教研室，山西 长治 046000

      卷次： 2019年30卷8期

      【摘要】 复发性自然流产(recurrent spontaneous abortion，RSA)是指同一性伴侣连续发生2次及2次以上的自然流产，其发病率占育龄期妇女的1%~3%。其病因非常复杂，常见发病原因有胚胎染色体异常、黄体功能不足、生殖器官异常、内分泌失常和自身免疫异常几大方面，其中免疫异常所导致的习惯性流产的发病机制和治疗仍是一个相当棘手的问题。该病的发病机制及诊疗仍旧是当今围生医学界的热门研究之一，基于当前的实践报道和研究现状，本文主要就免疫异常对复发性流产作用机制的研究进展做一综述。
      【关键词】 自然流产；免疫异常；自身抗体；发病机制；研究进展
      【中图分类号】 R714.21 【文献标识码】 A 【文章编号】 1003—6350（2019）08—1069—04

Research progress on mechanism of abnormal immune abortion.
ZHAI Zhi-cheng, SUN Wen-xia. Department ofObstetrics and Gynecology, Changzhi Medical College, Changzhi 046000, Shaanxi, CHINA【Abstract】 Recurrent spontaneous abortion (RSA) refers to repeated occurrence of two or more spontaneousabortions (with the same partner), occurring at a rate of 1% to 3% for women of childbearing age. The etiology is verycomplicated, and the common causes include embryonic chromosomal abnormalities, luteal dysfunction, reproductive or-gan abnormalities, endocrine disorders and autoimmune abnormalities. However, the pathogenesis and treatment of habit-ual abortion caused by immune abnormalities is still quite a difficult problem. The pathogenesis and diagnosis of the dis-ease is still one of the hotspots in the perinatal medical field. Based on the current practice reports and research status,this paper reviews the research progress of immune abnormalities on the mechanism of recurrent spontaneous abortion.
      【Key words】 Spontaneous abortion (RSA); Immune abnormalities; Autoantibodies; Pathogenesis; Research progress·综述·doi:10.3969/j.issn.1003-6350.2019.08.033