标题：慢性肾脏病治疗的新靶点—连接蛋白43

      作者：汪琪，李玉斌    三峡大学人民医院宜昌市第一人民医院肾内科，湖北 宜昌 443000

      卷次： 2019年30卷8期

      【摘要】 慢性肾脏病(chronic kidney disease，CKD)是一种不可治愈性疾病，随着该病发病率不断增加，死亡率也逐年递增。由于目前尚无有效的治疗或改善预后的方案，所以当CKD病情进展至终末期肾病阶段，只能选择透析或移植进行肾脏替代治疗，继而引发了关于慢性肾脏病治疗方面的热潮。了解参与CKD进展的分子机制和所涉及的途径，有助于识别新的和更有效的治疗靶点。近来连接蛋白43 (Connexin43，Cx43)被认为是CKD发展过程中的一个新角色，在不同的肾细胞群中存在新的表达和(或)不同的定位，参与介导炎症和纤维化过程，从而导致肾脏损害。本文从Cx43及其与CKD相关性研究的角度出发，探讨CKD治疗的新靶点，并对CKD治疗的新靶点的发展前景加以展望。
      【关键词】 慢性肾脏病；炎症；纤维化；连接蛋白43；靶向治疗
      【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350（2019）08—1066—04

A new target for the treatment of chronic kidney disease-Connexin 43.
WANG Qi, LI Yu-bin. NephrologyDepartment, the First Hospital of Yichang, Yichang 443000, Hubei, CHINA【Abstract】 Chronic kidney disease (CKD) is an incurable disease. With the increase of incidence, the mortalityrate is increasing year by year. Since there is no effective treatment or plan to improve the prognosis at present, whenCKD progresses to the stage of end-stage kidney disease, only dialysis or transplantation can be selected for renal re-placement therapy, which then triggers a wave of treatment for chronic kidney disease. Understanding the molecularmechanisms and pathways involved in the progress of CKD can help identify new and more effective therapeutic targets.Recently, Connexin 43 (Cx43) has been considered to be a new role in the development of CKD, which has new expres-sion and/or different localization in different renal cell populations and is involved in mediating inflammation and fibro-sis causing kidney damage. This article explores the new targets of CKD treatment from the perspective of Cx43 and itscorrelation with CKD, and prospects for the development of new targets for CKD treatment.
      【Key words】 Chronic kidney disease; Inflammation; Fibrosis; Connexin 43; Targeted therapy·综述·doi:10.3969/j.issn.1003-6350.2019.08.032