标题：规范化抗梅毒治疗妊娠合并梅毒患者的效果分析

      作者：刘荣，王浩哲    陕西省友谊医院妇产科，陕西 西安 710069

      卷次： 2019年30卷8期

      【摘要】 目的 探讨规范化抗梅毒治疗对妊娠合并梅毒患者围产结局的影响。方法 回顾性分析2010年1月至2017年10月在陕西省友谊医院妇产科收治的101例妊娠合并梅毒患者的临床资料，根据是否接受规范化抗梅毒治疗将患者分为规范治疗组(n=59)和非规范治疗组(n=42)，比较两组患者的早产、新生儿死亡及先天梅毒情况。结果 规范治疗组患者的早产及先天梅毒的发生率分别为3.39%、14.29%，明显低于非规范治疗组的14.29%、16.67%，差异均有统计学意义(P<0.05)；规范治疗组及非规范治疗组患者新生儿死亡率(0和2.38%)比较差异无统计学意义(P>0.05)。结论 规范化的抗梅毒治疗可有效改善妊娠合并梅毒患者的妊娠结局、降低先天梅毒儿的发生率。
      【关键词】 妊娠；梅毒；苄星青霉素；规范化治疗；早产
      【中图分类号】 R714.259 【文献标识码】 A 【文章编号】 1003—6350（2019）08—1044—03

Effect of standardized anti-syphilis therapy in pregnant women with syphilis.
LIU Rong, WANG Hao-zhe.Department of Obstetrics and Gynecology, Shaanxi Friendship Hospital, Xi'an 710069, Shaanxi, CHINA
【Abstract】 Objective To explore the effect of standardized anti-syphilis treatment on perinatal outcome ofpregnant women with syphilis. Methods The clinical data of 101 women of pregnancy combined with syphilis were se-lected in Department of Obstetrics and Gynecology, Shaanxi Friendship Hospital from Jan. 2010 to Oct. 2017 was retro-spectively analyzed. According to whether the patients received standardized anti-syphilis treatment or not, the patientswere divided into the standard treatment group (n=59) and the non-standard treatment group (n=42). The prematurebirth, neonatal death, and congenital syphilis were compared between the two groups. Results The incidence of prema-ture birth and congenital syphilis in the standard treatment group was 3.39% and 14.29%, respectively, which was signifi-cantly lower than 14.29% and 16.67% in the non-standard treatment group (P<0.05). There was no statistically signifi-cant difference in neonatal mortality between the two groups: 0 vs 2.38%, P>0.05. Conclusion Standardized anti-syphi-lis treatment can effectively improve pregnancy outcomes and reduce the incidence of congenital syphilis in pregnantwomen with syphilis.
      【Key words】 Pregnancy; Syphilis; Benzylpenicillin; Standardized treatment; Premature birth·短篇论著·doi:10.3969/j.issn.1003-6350.2019.08.027