标题：妊娠期糖尿病对新生儿并发症及骨密度的影响

      作者：谭开卷，佘意贵，洪秀红，周燕    阳江市妇幼保健院儿科，广东 阳江 529500

      卷次： 2019年30卷8期

      【摘要】 目的 探讨妊娠期糖尿病对新生儿并发症及骨密度的影响。方法 选取阳江市妇幼保健院儿科2016年11月至2018年2月妊娠期糖尿病产妇所生的足月新生儿150例作为观察组，随机抽取同期正常产妇所生的足月新生儿150例作为对照组。检测两组新生儿体质量、出生后1 h、6 h、24 h血糖水平、出生后1 h红细胞压积及血清C反应蛋白(CRP)水平、沿骨轴传播的超声波速度(SOS值)，进而分析比较两组新生儿并发症发生率及骨密度。结果 观察组和对照组的新生儿出生体质量[(3 528.22±425.73) g vs (3 409.56±453.28) g]、出生后 1 h血糖[(3.13±0.42) mmol/L vs (3.94±0.54) mmol/L]、出生后6 h血糖[(3.95±0.51) mmol/L vs (4.16±0.58) mmol/L]、出生后1 h红细胞压积[(55.48±7.59)% vs (51.73±6.13)%]、血清CRP水平[(3.54±0.49) mg/L vs (3.32±0.46) mg/L]、新生儿低血糖症发生率(13.33% vs 3.33%)、大于胎龄儿发生率(12.67% vs 5.33%)、感染发生率(14.00% vs 6.67%)、红细胞增多症发生率(9.33% vs 2.00%)、先天心脑畸形发生率(8.67% vs 1.33%)、新生儿 7 d龄时 SOS值[(2 705.29±351.13) m/s vs(2 809.36±383.27) m/s]比较差异均具有统计学意义(P<0.05)。结论 妊娠期糖尿病能增加新生儿低血糖症、大于胎龄儿、感染、红细胞增多症、先天心脑畸形等并发症发生率，同时对新生儿骨密度产生不良影响，故需早期诊断并干预。
      【关键词】 妊娠期糖尿病；新生儿；骨密度；低血糖症；感染；先天畸形
      【中图分类号】 R714.256 【文献标识码】 A 【文章编号】 1003—6350（2019）08—1024—04

Effect of gestational diabetes mellitus on neonatal complications and bone mineral density.
TAN Kai-juan, SHEYi-gui, HONG Xiu-hong, ZHOU Yan. Department of Pediatrics, Yangjiang Maternal and Child Health Hospital, Yangjiang529500, Guangdong, CHINA
【Abstract】 Objective To investigate the effect of gestational diabetes mellitus on neonatal complications andbone mineral density. Methods From November 2016 to February 2018, 150 full-term neonates of woman with gesta-tional diabetes mellitus were selected as observation group, who were born in the Department of Pediatrics at YangjiangMaternal and Child Health Hospital. Another 150 full-term neonates of normal puerperants born in the same period wererandomly selected as control group. The body weight of newborns in the two groups was measured, as well as blood glu-cose levels at 1 h, 6 h and 24 h after birth, hematocrit at 1 h after birth, serum C reactive protein (CRP) levels, and speedof sound waves propagating along the bone axis (SOS value), then the incidence of neonatal complications and bone min-eral density were analyzed and compared in the two groups. Results Between the observation group and the con-trol group, all differences were statistically significant (P<0.05) in the neonatal body weight (3 528.22±425.73) g