标题：血小板减少症患者抗核抗体与抗核抗体谱的表达与其年龄和性别的关系

      作者：秦伟，韩红满，左立辉，孙克，李四强    中国人民解放军第252医院肿瘤血液科，河北 保定 071000

      卷次： 2019年30卷7期

      【摘要】 目的 探讨血小板减少症患者抗核抗体(ANA)和抗核抗体谱(ANAs)的表达与其年龄和性别的关系。方法 选取中国人民解放军第252医院肿瘤血液科2010年1月至2015年5月收治的123例初治的原发免疫性血小板减少症住院患者，根据患者年龄划分为三组，年龄1~20岁为A组(n=13例)，其中男性4例，女性9例；年龄21~60岁为B组(n=87例)，其中男性26例，女性61例，年龄≥61岁为C组(n=23例)，其中男性10例，女性13例，各组再按照性别分为男性组及女性组，均经ANA与ANAs筛查，分析各组患者ANA及ANAs阳性情况。结果 (1) B组及C组患者ANA阳性率分别为35.6%及39.1%，均高于A组的23.1%，但差异均无统计学意义(P>0.05)；A组患者的女性ANA阳性率为 33.3%，高于本组男性的 0，C组女性为 46.2%，高于本组男性的 30.0%，但差异均无统计学意义(P>0.05)；B组女性ANA阳性率为46.0%，高于本组男性的11.5%，差异有统计学意义(P<0.05)；三组所有患者女性ANA总阳性率为 44.6%，明显高于三组所有男性的 15.0%，差异有显著统计学意义(P<0.01)。(2) B组及C组患者ANAs阳性率分别为 49.1%及 43.4%，均高于A组的 23.1%，但差异均无统计学意义(P>0.05)；A组患者的男性ANAs阳性率为25.0%，高于本组女性的22.2%，差异无统计学意义(P>0.05)；B组女性ANAs阳性率为59.0%，高于本组男性的26.9%，差异有统计学意义(P<0.05)；C组女性ANAs阳性率为46.1%，高于本组男性的40.0%，差异无统计学意义(P>0.05)；三组患者所有女性ANAs的总阳性率为53.0%，明显高于三组所有男性的22.5%，差异有显著统计学意义(P<0.01)。结论 ANA与ANAs在血小板减少症患者中的表达随着年龄增长有增高趋势，女性阳性率高于男性，对育龄期及更年期血小板减少患者尤其应进行ANA及ANAs筛查。
      【关键词】 原发免疫性血小板减少症；自身免疫性疾病；抗核抗体；抗核抗体谱；性别；年龄
      【中图分类号】 R558+.2 【文献标识码】 A 【文章编号】 1003—6350（2019）07—0836—03

Relationship between expression of antinuclear antibody and antinuclear antibody spectrum in patients withthrombocytopenia and their gender and age.
QIN Wei, HAN Hong-man, ZUO Li-hui, SUN Ke, LI Si-qiang.Department of Hematology and Endocrinology, the 252nd Hospital of Chinese PLA, Baoding 071000, Hebei, CHINA
【Abstract】 Objective To investigate the association of expressions of antinuclear antibody (ANA) and antinu-clear antibody spectrum (ANAs) in patients with thrombocytopenia and their age and gender. Methods A total of 123patients with newly diagnosed primary immune thrombocytopenia in Department of Hematology and Endocrinology, the252nd Hospital of Chinese PLA from January 2010 to May 2015, were selected. They were divided into three groups byage: group A (1-20 years, 13 cases, including 4 males and 9 females, group B (21-60 years, 87 cases, including 26 malesand 61 females), group C (≥61 years, 23 cases, including 10 males and 13 females). Each group was divided into malegroup and female subgroups by gender. ANA and ANAs of all patients were inspected, and the expression rates of ANAand ANAs were analyzed among different groups. Results (1) The ANA positive rates in group B and group C were35.6% and 39.1%, respectively, as compared with 23.1% in group A (P>0.05). The ANA positive rates of female pa-tients in group A was 33.3%, as compared with 0 of male patients in group A (P>0.05). The ANA positive rates offemale patients in group C was 46.2%, as compared with 30.0% of male patients in group C (P>0.05). The ANA positiverates of female patients in group B was 46.0%, as compared with 11.5% of male patients in group B (P<0.05). The ANAtotal positive rates of female patients in three groups was 44.6%, as compared with 15.0% of male patients inthree groups (P<0.05). (2) The ANAs positive rates in group B and group C were 49.1% and 43.4%, respectively, as com-pared with 23.1% in group A (P>0.05). The ANAs positive rates of female patients in group A was 25.0%, as comparedwith 22.2% of male patients in group A (P>0.05). The ANAs positive rates of female patients in group B was 59.0%, ascompared with 26.9% of male patients in group B (P<0.05). The ANAs positive rates of female patients in group C was46.1%, as compared with 40.0% of male patient in group C (P>0.05). The ANAs total positive rates of female patients inthree groups were 53.0%, as compared with 22.5% of male patients in three groups (P<0.05). Conclusion Along withthe growth of the age, expressions of ANA and ANAs in patients with thrombocytopenia was more and more higher. Theincidence of thrombocytopenia in female patients was higher than that in male patients. In particular, ANA and ANAsshould be screened for the patients of childbearing age and menopause with thrombocytopenia.
      【Key words】 Primary immune thrombocytopenia; Autoimmune disease; Antinuclear antibody; Antinuclear anti-body spectrum; Gender; Age