标题：欣普贝生对宫颈未成熟足月妊娠产妇分娩方式和妊娠结局的影响

      作者：郭芸，党晓贤，潘有焕    商洛市中医医院妇产科，陕西 商洛 726000

      卷次： 2019年30卷6期

      【摘要】 目的 探讨欣普贝生对宫颈未成熟足月妊娠产妇分娩方式和妊娠结局的影响。方法 选择2017年1月至2018年10月期间在商洛市中医医院妇产科住院的92例宫颈未成熟足月妊娠产妇为研究对象，根据随机数表法将其分为观察组与对照组，每组46例。对照组使用缩宫素促宫颈成熟，观察组则应用欣普贝生。比较两组产妇用药前后宫颈Bishop评分，评估促宫颈成熟效果，同时记录产妇分娩方式及新生儿窒息、高胆红素血症发生率以及新生儿Apgar评分。结果 用药后6 h、12 h，观察组产妇宫颈Bishop评分分别为(5.69±1.34)分、(7.62±1.51)分，均明显高于对照组的(4.10±0.86)分、(5.58±1.12)分，差异均有统计学意义(P<0.05)；观察组产妇的促宫颈成熟总有效率为93.48%，明显高于对照组的73.91%，产妇剖宫产率为26.09%，明显低于对照组的45.65%，新生儿高胆红素血症发生率为 2.17%，也明显低于对照组的 13.04%，差异均有统计学意义(P<0.05)；观察组新生儿窒息发生率、新生儿Apgar评分分别为 2.17%、(9.35±1.25)分，与对照组的 4.35%、(9.24±1.08)分比较差异均无统计学意义(P>0.05)。结论 欣普贝生应用于宫颈未成熟足月妊娠产妇，可以有效促进宫颈成熟，降低剖宫产率，从而改善母婴结局，且具有较高的安全性。
      【关键词】 欣普贝生；缩宫素；宫颈成熟；足月妊娠引产；分娩方式；高胆红素血症
      【中图分类号】 R714.2 【文献标识码】 A 【文章编号】 1003—6350（2019）06—0750—03

Effect of Propess on the delivery mode and pregnancy outcome of full-term pregnant women with immaturecervix.
GUO Yun, DANG Xiao-xian, PAN You-huan. Department of Obstetrics and Gynecology, Shangluo TraditionalChinese Medicine Hospital, Shangluo 726000, Shaanxi, CHINA
【Abstract】 Objective To investigate the effect of Propess (Dinoprostone Suppositories) on the delivery modeand pregnancy outcome of full-term pregnant women with immature cervix. Methods A total of 92 cases of cervicalimmature full-term pregnant women were selected as subjects, who were hospitalized in the Department of Obstetricsand Gynecology at Shangluo Traditional Chinese Medicine Hospital from January 2017 to October 2018. According tothe random number table method, they were divided into observation group and control group, with 46 cases in eachgroup. The control group was treated with Oxytocin to promote cervical ripening, while the observation group was treat-ed with Propess. The Bishop scores of the cervix before and after maternal administration were compared between thetwo groups, and the cervical ripening effect was evaluated. The mode of delivery, the incidence of neonatal asphyxia andhyperbilirubinemia, and the Apgar score of neonates were recorded at the same time. Results At 6 h and 12 h after med-ication, the Bishop score of maternal cervixes was respectively 5.69±1.34 and 7.62±1.51 in the observation group, whichwere significantly higher than corresponding 4.10±0.86 and 5.58±1.12 in the control group (P<0.05). In the observationgroup, the total effective rate of cervical ripening was 93.48%, which was significantly higher than 73.91% in the controlgroup; the maternal cesarean section rate was 26.09%, which was significantly lower than 45.65% in the control group;the incidence of neonatal hyperbilirubinemia was 2.17%, which was also significantly lower than 13.04% in the controlgroup; all differences were statistically significant (P<0.05). The incidence of neonatal asphyxia and Apgar score were re-spectively 2.17% and 9.35±1.25 in the observation group, compared with corresponding 4.35% and 9.24±1.08 in the con-trol group, with no statistically significant differences (P>0.05). Conclusion The application of Propess (DinoprostoneSuppositories) in full-term pregnant women with immature cervix can effectively promote cervical ripening, reduce therate of cesarean section, thereby improving maternal and infant outcomes, and has high safety.
      【Key words】 Propess; Oxytocin; Cervical ripening; Induced labor of full-term pregnancy; Mode of delivery; Hy-perbilirubinemia