标题：术后谵妄危险因素的研究进展

      作者：杨露 1，唐珩 2，李艳华 3    1.昆明理工大学医学院，云南 昆明 650500；2.昆明理工大学附属医院云南省第一人民医院麻醉科，云南 昆明 650100；3.昆明理工大学附属医院云南省第一人民医院疼痛科，云南 昆明 650100

      卷次： 2019年30卷5期

      【摘要】 术后谵妄(POD)好发于老年人，是一种发病原因多、致病机制并不明确的中枢神经系统疾病，常发生在术后时期，通常出现在术后当天并持续到第6天。如及时诊断、发现并治疗，会大大提高患者的生活质量；如发现不及时，有极大可能转化为长期认知障碍，后果严重。本文从导致POD发生的术前、术中、术后的原因，探讨发生POD的危险因素及机制，为有效预防、及时发现、尽量避免发生POD提供可能。
      【关键词】 术后谵妄；危险因素；认知障碍；刺激；预防
      【中图分类号】 R619 【文献标识码】 A 【文章编号】 1003—6350（2019）05—658—05R

esearch progress of postoperative delirium risk factors.
YANG Lu 1, TANG Heng 2, LI Yan-hua 3. 1. KunmingUniversity of Science and Technology, Kunming 650500, Yunan, CHINA; 2. Affiliated Hospital of Kunming University ofScience and Technology/the First People Hospital of Yunnan Province, Kunming 650100, Yunan, CHINA; 3. AffiliatedHospital of Kunming University of Science and Technology/the First People Hospital of Yunnan Province, Kunming 650100,Yunan, CHINA【Abstract】 Postoperative delirium (POD) is a kind of central nervous system disease with multiple causes andunclear pathogenesis, which often occurs on day 0 after surgery and lasts until the 6th day after surgery. If diagnosed, dis-covered and treated in time, the quality of life of patients will be greatly improved, otherwise it is likely to be trans-formed into long-term cognitive impairment with serious consequences. This review analyzes the risk factors and mecha-nism of POD from preoperative, intraoperative and postoperative causes, which provides the possibility for effective pre-vention, timely detection, and avoiding POD.
      【Key words】 Postoperative delirium; Risk factors; Cognitive impairment; Stimulation; Prevention·综述·doi:10.3969/j.issn.1003-6350.2019.05.034基金项目：云南省卫生科技计划项目(编号：2014NS245)