标题:乳腺癌患者血液学指标和临床特征分析
作者:谢晓琳 1,阳小群 1,李梦璐 2,廖兵 1 1.重庆市第九人民医院检验科,重庆 400700;2.陆军军医大学附属第二医院检验科,重庆 400037
卷次:
2019年30卷2期
【摘要】 目的 探讨乳腺癌患者的血液学指标和临床特征,为乳腺癌的早期诊断提供科学依据。方法 回顾性分析2014年1月至2017年10月重庆市第九人民医院肿瘤科收治的136例乳腺癌患者(乳腺癌组)的检验与临床资料,以127例乳腺良性病变患者为对照组,收集并分析患者的血液学指标和临床特征,采用 t检验或χ2检验分析组间差异,采用多因素Logistic回归分析其危险因素。结果 乳腺癌组和乳腺良性病变组患者的年龄、是否绝经比较差异均有统计学意义(P<0.05);乳腺癌组患者的中性粒细胞百分比(NEUT%)、嗜碱性粒细胞数(BASO)、嗜碱性粒细胞百分比(BASO%)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)、平均血小板体积(MPV)、中性粒细胞数与淋巴细胞数比值(NLR)分别为(63.62±7.56)%、(0.04±0.038)×109/L、(0.50±0.315)%、(87.85±5.70) fL、(28.98±2.80) pg、(331.2±17.48) g/L、(8.66±0.95) fL和(2.54±0.99),乳腺良性病变组患者分别为(61.16±7.49)%、(0.03±0.013)×109/L、(0.43±0.214)%、(85.46±7.51) fL、(27.96±3.54) pg、(326.0±18.80) g/L、(8.43±0.84) fL和(2.25±0.79),两组比较,乳腺癌组均高于乳腺良性病变组,差异均有统计学意义(P<0.05);乳腺癌组患者淋巴细胞数(LYMPH)、淋巴细胞百分比(LYMPH%)、红细胞数(RBC)分别为(1.85±0.52)×109/L、(27.46±6.76)%和(4.59±0.43)×1012/L,乳腺良性病变组患者分别为(1.98±0.50)×109/L、(29.48±6.81)%和(4.70±0.44)×1012/L,两组比较,乳腺癌组均低于乳腺良性病变组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄、BASO、MPV是乳腺癌的危险因素。结论 乳腺癌患者常伴有血液学指标和临床特征的异常,并且年龄、BASO和MPV可作为乳腺癌诊断的重要参考指标。
【关键词】 乳腺癌;血液学指标;临床特征;危险因素;早期诊断
【中图分类号】 R737.9 【文献标识码】 A 【文章编号】 1003—6350(2019)02—186—03A
nalysis of hematological indexes and clinical features in breast cancer patients.
XIE Xiao-lin 1, YANG Xiao-qun 1,LI Meng-lu 2, LIAO Bing 1. 1. Department of Clinical Laboratory, the Ninth People's Hospital of Chongqing, Chongqing400700, CHINA; 2. Department of Clinical Laboratory, Army Medical University, Chongqing 400037, CHINA
【Abstract】 Objective To investigate hematological indexes and clinical features of breast cancer patients, andto provide scientific evidence for early diagnosis of breast cancer. Methods A total of 136 patients with breast cancertreated in Ninth People's Hospital of Chongqing between January 2014 and October 2017 were recruited as breast cancergroup, and 127 patients of benign breast lesions selected as control group. Hematological indexes and clinical featureswere collected, and differences between groups were analyzed by t test or χ2 test. Risk factors were analyzed by multivari-ate logistic regression analysis. Results There were significant differences in age, menopause between breast cancer pa-tients and patients with benign breast lesions (P<0.05). Levels of neutrophil percentage (NEUT%), basophil (BASO), ba-sophil percentage (BASO%), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscularhemoglobin concentration (MCHC), mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR) in breast cancerpatients were (63.62±7.56)%, (0.04±0.038)×109/L, (0.50±0.315)%, (87.85±5.70) fL, (28.98±2.80) pg, (331.2±17.48) g/L,(8.66 ± 0.95) fL and (2.54 ± 0.99) respectively, significantly higher than (61.16 ± 7.49)% , (0.03 ± 0.013) × 109/L, (0.43 ±0.214)%, (85.46±7.51) fL, (27.96±3.54) pg, (326.0±18.80) g/L, (8.43±0.84) fL and (2.25±0.79) in patients with benignbreast lesions (P<0.05). Levels of lymphocyte (LYMPH), lymphocyte percentage (LYMPH%), red blood cell (RBC) inbreast cancer patients were (1.85±0.52)×109/L, (27.46±6.76)% and (4.59±0.43)×1012/L, significantly lower than (1.98±0.50)×109/L, (29.48±6.81)% and (4.70±0.44)×1012/L in patients with benign breast lesions (P<0.05). Logistic regressionanalysis showed that age, BASO, MPV were risk factors for breast cancer. Conclusion Breast cancer patients may becommonly accompanied with abnormal hematological indexes and clinical features, and age, BASO, MPV can be consid-ered as important reference indexes for the diagnosis of breast cancer.
【Key words】 Breast cancer; Hematological indexes; Clinical features; Risk factors; Early diagnosis
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