标题：2型糖尿病肾病患者血清晚期氧化蛋白产物与动脉粥样硬化的关系

      作者：荣光 1，卓华钦 1，叶庆邦 1，宁海欢 1，朱咏瑶 2，杨银广 3，林志坚 4，蔡茵瑜 5    东莞市第三人民医院肾内科 1、内分泌科 2、功能检查科B超室 3、检验科 4、健康管理科 5，广东 东莞 523326

      卷次： 2019年30卷2期

      【摘要】 目的 探讨2型糖尿病肾病患者血清晚期氧化蛋白产物(AOPP)与动脉粥样硬化的关系。方法 检测2017年7月至2018年6月在东莞市第三人民医院住院治疗的50例2型糖尿病肾病(非透析)患者、30例单纯2型糖尿病患者(无并发症)及30例健康体检者血清AOPP的含量，彩色多普勒超声测量颈动脉内中膜厚度(IMT)。通过多变量偏相关分析研究AOPP与动脉粥样硬化的相关性。结果 2型糖尿病肾病组及单纯2型糖尿病组患者血清AOPP[(76.83±4.96) μmol/L、(60.28±3.92) μmol/L]较健康对照组[ (26.91±2.18) μmol/L]显著升高，差异均有统计学意义(P<0.05)；2型糖尿病肾病患者中 IMT正常组患者的血清AOPP为(35.28±3.92) μmol/L，明显低于 IMT增厚组的(61.83±4.96) μmol/L，差异有统计学意义(P<0.05)；且多变量相关分析表明,血清AOPP与颈动脉 IMT值呈显著正相关性(r=0.335，P<0.01)。结论 2型糖尿病肾病患者血清AOPP与颈动脉 IMT呈正相关，可能促进2型糖尿病肾病患者动脉粥样硬化的发生发展。
      【关键词】 2型糖尿病肾病；2型糖尿病；氧化蛋白产物；动脉粥样硬化
      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2019）02—166—03R

elationship between serum advanced oxidation protein products and atherosclerosis in patients with type 2diabetic nephropathy.
RONG Guang 1, ZHUO Hua-qin 1, YE Qing-bang 1, NING Hai-huan 1, ZHU Yong-yao 2, YANGYin-guang 3, LIN Zhi-jian 4, CAI Yin-yu 5. Department of Nephrology 1, Department of Endocrinology 2, B-ultrasoundRoom, Department of Functional Examination 3, Department of Clinical Laboratory 4, Department of Health Management 5,Third People's Hospital of Dongguan, Dongguan 523326, Guangdong, CHINA
【Abstract】 Objective To explore the relationship between advanced oxidation protein products (AOPP) andatherosclerosis (AS) in patients with type 2 diabetic nephropathy. Methods A total of 50 patients with type 2 diabeticnephropathy (non-dialysis) hospitalized in the Third People's Hospital of Dongguan from July 2017 to June 2018, 30 pa-tients with type 2 diabetes mellitus (without complications), and 30 healthy subjects were examined for AOPP content.The mean intima-media thickness (IMT) of carotid artery was measured by ultrasonography. Correlation between AOPPand atherosclerosis was studied by multivariate partial correlation analysis. Results Serum AOPP in the type 2 diabeticnephropathy group and the type 2 diabetes mellitus group were (76.83±4.96) μmol/L, (60.28±3.92) μmol/L, significantlyhigher than (26.91±2.18) μmol/L in the healthy control group (P<0.05). Serum AOPP in type 2 diabetic nephropathy pa-tients with normal IMT was (35.28±3.92) μmol/L, which was significantly lower than (61.83±4.96) μmol/L in the pa-tients with IMT thickening (P<0.05). Multivariate correlation analysis showed a significant positive correlation betweenserum AOPP and carotid IMT (r=0.335, P<0.01). Conclusion In patients with type 2 diabetic nephropathy, AOPP waspositively correlated with carotid artery IMT and may involved in the occurrence and development of atherosclerosis.
      【Key words】 Type 2 diabetic nephropathy; Type 2 diabetes mellitus; Advanced oxidation protein products; Ath-erosclerosis