标题：生殖道B族溶血性链球菌感染与先兆流产及先兆早产的相关性

      作者：张华 1，杨爱玲 1，郭亚菊 2    (1.延安市富县人民医院妇产科，陕西 延安 727500；2.西安医学院第二附属医院内分泌科，陕西 西安 710038)

      卷次： 2018年29卷23期

      【摘要】 目的 探讨生殖道B族溶血性链球菌(GBS)感染与先兆流产及先兆早产的相关性。方法 选取延安市富县人民医院妇产科2016年5月至2017年5月因先兆流产及先兆早产的孕妇80例纳入观察组，同期再选取100例健康孕妇作为对照组，统计生化检验结果。应用Pearson相关分析GBS感染和先兆流产及先兆早产的相关性。结果 观察组GBS培养结果阳性18例，占22.5%，明显高于对照组的9.0%，差异具有统计学意义(P<0.05)；观察组霉菌的发生率为17.5%，明显高于对照组的7.0%，两组比较差异具有统计学意义(P<0.05)；观察组混合感染的发生率为27.5%，明显高于对照组的15.0%，两组比较差异具有统计学意义(P<0.05)；观察组孕妇的细菌性阴道病和滴虫的发生率分别为12.5%和6.25%，对照组则分别为9.0%和5.0%，两组比较差异无统计学意义(P>0.05)；Pearson相关分析结果显示，GBS感染和先兆流产及先兆早产具有相关性(r=0.173，P<0.05)。结论 先兆流产及先兆早产与孕妇生殖道GBS感染有着密切的联系，行相关病原体筛查是必要的。
      【关键词】 B族溶血性链球菌；先兆流产；先兆早产；相关性
      【中图分类号】 R714.21 【文献标识码】 A 【文章编号】 1003—6350（2018）23—3354—03

Relationship between group B Streptococci infection in reproductive tract and threatened abortion, threatenedpremature labor.
ZHANG Hua 1, YANG Ai-ling 1, GUO Ya-ju 2. Department of Obstetrics and Gynecology, Fu CountyPeople's Hospital, Yan'an 727500, Shaanxi, CHINA; 2. Department of Endocrinology, the Second Affiliated Hospital of Xi'anMedical University, Xi'an 710038, Shaanxi, CHINA
【Abstract】 Objective To investigate the relationship between group B Streptococci infection (GBS) in repro-ductive tract and threatened abortion and threatened premature labor. Methods Eighty pregnant women with threat-ened abortion and threatened premature labor in Department of Obstetrics and Gynecology, Fu County People's Hospitalfrom May 2016 to May 2017 were selected as the observation group. During the same period, 100 healthy pregnant wom-en were selected as the control group. The results of biochemical tests were statistically analyzed. Pearson correlationanalysis was used to analyze the relationship between GBS infection and threatened abortion and threatened prematurelabor. Results The GBS culture results were positive in 18 cases in the observation group, and the positive rate was22.5%, significantly higher than (9.0%) in the control group (P<0.05). The incidence of mould in the observation groupwas 17.5%, which was significantly higher than 7.0% in the control group (P<0.05). The incidence of mixed infectionwas 27.5% in the observation group, which was significantly higher than 15% in the control group (P<0.05). The inci-dence of bacterial vaginosis and Trichomonas infection was 12.5% and 6.25% in the observation group, versus 9.0% and5.0% in the control group (P>0.05). Pearson correlation analysis showed that GBS infection was associated with threat-ened abortion and threatened premature labor (r=0.173, P<0.05). Conclusion Threatened abortion and threatened pre-mature labor are closely related to GBS infection in the reproductive tract of pregnant women. Screening of the relatedpathogens is necessary.
      【Key words】 Group B Streptococcus; Threatened abortion; Threatened premature labor; Relationship·短篇论著·doi:10.3969/j.issn.1003-6350.2018.23.031基金项目：陕西省自然科学发展项目(编号：XZ-4132)