标题：复合营养维生素补充治疗对3~6岁儿童的营养、发育状况的影响

      作者：陈文霞 1，郭焕利 1，张雪 1，黄继刚 1，张森山 2    (安康市中心医院儿童保健科 1、新生儿科 2，陕西 安康 725000)

      卷次： 2018年29卷23期

      【摘要】 目的 探讨复合营养维生素补充治疗对3~6岁儿童营养、发育状况的影响。方法 选取2016年1月至2017年1月来安康市中心医院儿童保健科体检的320名健康儿童为研究对象，按照随机数表法将入选儿童分为观察组和照组，每组160名。对照组儿童单纯给予补充维生素A，观察组儿童给予补充复合营养维生素，均连续服用6个月。分别于干预前后测量两组儿童的身高、体质量、血清维生素A、钙、铁、锌水平，比较两组儿童营养不良发生情况。结果 干预前观察组和对照组儿童的身高[(103.4±5.7) cm vs (103.2±5.3) cm]、体质量[(16.8±1.5) kg vs(16.5±1.4) kg]、维生素A [(120.5±7.8) μmol/L vs (120.3±7.7) μmol/L]、钙[(2.52±0.23) mmol/L vs (2.50±0.21) mmol/L]、铁[(17.5±5.0) μmol/L vs (17.4±5.1) μmol/L]及锌[(12.3±2.1) μmol/L vs (12.2±2.0) μmol/L]比较差异均无统计学意义(P<0.05)；干预后，两组儿童的身高、体质量、维生素A、钙、铁及锌水平均升高，且观察组改善情况优于对照组[身高：(109.6±6.2) cm vs (106.4±5.9) cm；体质量：(19.7±1.8) kg vs (17.4±1.6) kg；维生素A：(125.6±8.6) μmol/L vs (122.9±7.9) μmol/L；钙：(2.58±0.25) mmol/L vs (2.37±0.20) mmol/L;铁：(25.2±7.1) μmol/L vs (21.1±6.8) μmol/L；锌：(15.8±3.1) μmol/L vs(13.4±2.8) μmol/L]，差异均有统计学意义(P<0.05)；干预后，两组儿童的低体质量、消瘦、生长迟缓及总营养不良发生率较干预前略有降低，但差异均无统计学意义(P>0.05)。结论 儿童营养不良的发生可能与微量营养素缺乏有关，服用复合微量营养素补充剂可以明显改善3~6岁儿童的营养状况，促进儿童的正常生长发育。
      【关键词】 儿童；营养不良；微量营养素缺乏；复合营养维生素；营养状况
      【中图分类号】 R151 【文献标识码】 A 【文章编号】 1003—6350（2018）23—3336—03

Effect of multi-vitamin nutritional supplements on the nutrition and development status of children aged 3-6years.
CHEN Wen-xia 1, GUO Huan-li 1, ZHANG Xue 1, HUANG Ji-gang 1, ZHANG Sen-shan 2. Department of ChildHealthcare 1, Department of Neonatology 2, Ankang Central Hospital, Ankang 725000, Shaanxi, CHINA
【Abstract】 Objective To explore the nutritional and developmental status of 3-6-year-old children and the ef-fect of multi-vitamin nutritional supplements. Methods A total of 320 healthy children, who was performed physicalexamination in Department of Child Healthcare of Ankang Central Hospital from January 2016 to January 2017, were se-lected and divided into the observation group (n=160) and the control group (n=160) according to random number tablemethod. The children in the control group were given vitamin A supplementation only, while the children in the observa-tion group were given multi-vitamin nutritional supplements, all for 6 months. The height, body weight, serum vitaminA, calcium, iron and zinc levels were measured before and after the intervention, and the incidence of malnutritionwas compared between the two groups. Results There was no significant difference in height, body weight, vitaminA, calcium, iron and zinc levels between the observation group and the control group before intervention (P<0.05):(103.4±5.7) cm vs (103.2±5.3) cm, (16.8±1.5) kg vs (16.5±1.4) kg, (120.5±7.8) μmol/L vs (120.3±7.7) μmol/L, (2.52±0.23) mmol/L vs (2.50±0.21) mmol/L, (17.5±5.0) μmol/L vs (17.4±5.1) μmol/L, (12.3±2.1) μmol/L vs (12.2±2.0) μmol/L,respectively. The above levels of the two groups were all increased after the intervention, and the improvements in theobservation group were significantly better than those of the control group (P<0.05): (109.6±6.2) cm vs (106.4±5.9) cm,(19.7±1.8) kg vs (17.4±1.6) kg, (125.6±8.6) μmol/L vs (122.9±7.9) μmol/L, (2.58±0.25) mmol/L vs (2.37±0.20) mmol/L,(25.2±7.1) μmol/L vs (21.1±6.8) μmol/L, (15.8±3.1) μmol/L vs (13.4±2.8) μmol/L, respectively. The incidence of lowbody weight, emaciation, growth retardation and total malnutrition in the two groups was slightly lower than that beforethe intervention, but the differences were not statistically significant (P>0.05). Conclusion The occurrence of malnutri-tion in children may be related to micronutrient deficiency. Micronutrient compound supplements can significantly im-prove the nutritional status of children aged 3-6 years and promote their normal growth and development.
      【Key words】 Children; Malnutrition; Micronutrient deficiency; Multi-vitamin nutritional supplements; Nutrition-al status·论 著·doi:10.3969/j.issn.1003-6350.2018.23.025基金项目：陕西省卫生厅科研基金项目(编号：2016JP25075)