标题：淮安地区人乳头瘤病毒感染现状及其与宫颈病变的相关性

      作者：王慧 1，胡芳君 1，辜卫红 1，徐妍 1，万娟 2    (1.淮安市妇幼保健院皮肤科，江苏 淮安 223001；2.淮安市金湖县妇幼保健所，江苏 金湖 211600)

      卷次： 2018年29卷22期

      【摘要】 目的 探讨淮安地区妇女宫颈人乳头瘤病毒感染现状及其与宫颈病变的相关性。方法 对2014年10月至2016年8月在淮安市妇幼保健院妇科开展宫颈癌筛查的2 952例妇女行宫颈液基细胞学检查和人乳头状瘤病毒(HPV)检测，对其HPV的感染状况、亚型分布及其与宫颈病变间的关系进行分析。结果 2 952例标本中检出HPV阳性者622例，感染率为21.07%，HPV感染率随年龄增加而升高；622例HPV阳性者中发生两种及以上亚型感染者163例，占26.21%，以二重感染较为常见，HPV多重感染比例随病变程度的加重而增加；高危型最常见型别依次为16、52、58，低危型依次为43、42、6；此外，高度子宫颈上皮内瘤变(CIN)病变(含CINⅡ、CINⅢ、宫颈癌)中最常见的基因型为16、52、33、58。结论 淮安地区妇女的颈病变严重程度与HPV感染密切相关，主要HPV基因亚型为16、52、58、33等，对这部分亚型感染者应密切随访，及时干预治疗，以预防宫颈癌的发生。
      【关键词】 人乳头瘤病毒；基因型；宫颈病变；相关性
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2018）22—3163—04

Current situation of HPV infection among the women and its relevance with cervical lesions in Huai’an city.WANG Hui 1, HU Fang-jun 1, GU Wei-hong 1, XU Yan 1, WANG Juan 2.
1. Dermatological Department, Huai'an Maternaland Child Health-Care Center, Huaian 223001, Jiangsu, CHINA; 2. Jinhu Maternal and Child Health-Care Center, Jinhu211600, Jiangsu, CHINA
【Abstract】 Objective To study the status of human papillomavirus (HPV) infection in cervix among the wom-en in Huai'an city, and to explore its correlation with cervical lesions. Methods A total of 2 952 women who were re-ceiving cervical cancer screening in Gynecological Department of Huai'an Maternal and Child Health-Care Center fromOctober 2014 to August 2016 underwent liquid based cytological test and HPV detection. The relationship between HPVinfection status, distribution of HPV subtypes and the degree of the diseases was analyzed. Results Among the 2 952samples, 622 samples were positive for HPV infection, and the infection rate was 21.07%. The rate of HPV infection in-creased with the increase of age. Among 622 HPV positive cases, 163 cases (26.21%) were infected by two or more sub-types of HPV, and furthermore, the double infections were common. The multiple HPV infection rate increased with theseverity of cervical lesions. The most prevalent high-risk HPV genotypes were HPV16, HPV52 and HPV58, while thelow-risk genotypes were HPV43, HPV42 and HPV6, respectively. Besides, the most common genotypes in high cervicalintraepithelial neoplasia (CIN) lesions, ontaining CINⅡ, CINⅢ and cervical cancer, were HPV16, HPV52, HPV33 andHPV58. Conclusion The severity of cervical lesions among the women in Huai’an was closely related to HPV infec-tion. The main HPV genotypes were HPV16, HPV52, HPV58 and HPV33, et al. The patients with those genotypes ofHPV infection should be followed up closely to prevent the occurrence of cervical cancer.
      【Key words】 Human papillomavirus; Genotype; Cervical lesions; Correlation·论 著·doi:10.3969/j.issn.1003-6350.2018.22.017