标题：氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死疗效观察

      作者：朱浩 1，鱼丽萍 1，杨霖崧 1，李文强 1，王小利 2    (1.咸阳市第一人民医院神经内科，陕西 咸阳 712000；2.中航工业西安医院内科，陕西 西安 710077)

      卷次： 2018年29卷22期

      【摘要】 目的 探讨氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死的临床疗效。方法 选择2018年1~7月期间咸阳市第一人民医院神经内科收治的90例急性脑梗死患者为研究对象，根据随机数表法分为对照组和观察组，每组 45例，对照组采用抗血小板等常规治疗，同时应用氟伐他汀治疗，观察组在此基础上联合应用丁苯酞治疗，疗程 14 d。比较两组患者治疗前后的美国国立卫生院神经功能缺损量表(NIHSS)评分、Barthel指数(BI)评分的变化，以及血清超敏C反应蛋白(hs-CRP)、白细胞介素-6 (IL-6)水平的变化，同时比较临床疗效。结果 治疗后，观察组患者的NIHSS及BI评分分别为(8.89±2.34)分、(64.57±17.67)分，明显优于对照组的(12.13±2.69)分、(55.69±15.48)分，差异均有统计学意义(P<0.05)；观察组患者治疗后的血清hs-CRP、IL-6水平分别为(11.36±3.21) mg/L、(19.54±6.18) ng/L，明显低于对照组的(14.73±3.88) mg/L、(24.37±7.02) ng/L，差异均具有统计学意义(P<0.05)；观察组患者的治疗总有效率为84.84%，明显高于对照组的68.89%，差异具有统计学意义(P<0.05)。结论 氟伐他汀联合丁苯酞软胶囊治疗急性脑梗死可以有效降低患者的血清炎症因子水平，改善患者的神经功能缺损及提高日常生活能力。
      【关键词】 急性脑梗死；氟伐他汀；丁苯酞；神经功能；日常生活能力；疗效
      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2018）22—3132—03

Efficacy of fluvastatin combined with butylphthalide soft capsule on acute cerebral infarction.
ZHU Hao 1, YULi-ping 1, YANG Lin-song 1, LI Wen-qiang 1, WANG Xiao-li 2. 1. Department of Neurology, the First People's Hospital ofXianyang City, Xianyang 712000, Shaanxi, CHINA; 2. Department of Medicine, Xi'an Hospital of China Aviation Industry,Xi'an 710077, Shaanxi, CHINA
【Abstract】 Objective To investigate the clinical efficacy of fluvastatin combined with butylphthalide soft cap-sule in the treatment of acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction treatedin Department of Neurology, the First People's Hospital of Xianyang City, from January 2018 to July 2018 were selectedand divided into a control group and an observation group according to the random number table method, with 45 casesin each group. The control group received routine antiplatelet therapy and fluvastatin treatment. The observation groupwas treated in combination with butylphthalide on this basis of above treatment; the course of treatment was 14 days.The National Institutes of Health Neurological Deficit Scale (NIHSS) score, Barthel index (BI) score, serum hypersensi-tive C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were compared between the two groups before and af-ter treatment, and the clinical effects were compared. Results After treatment, the NIHSS and BI scores in the observa-tion group were (8.89 ± 2.34) and (64.57 ± 17.67), respectively, which were significantly better than (12.13 ± 2.69) and(55.69±15.48) in the control group, and the differences were statistically significant (P<0.05); the serum hs-CRP andIL-6 levels in the observation group were (11.36±3.21) mg/L and (19.54±6.18) ng/L, respectively, significantly lowerthan (14.73±3.88) mg/L and (24.37±7.02) ng/L in the control group, the differences were statistically significant (P<0.05). The total effective rate of the observation group was 84.84%, significantly higher than that of the control group(68.89%), P<0.05. Conclusion Fluvastatin combined with butylphthalide soft capsule in the treatment of acute cere-bral infarction can effectively reduce the level of serum inflammatory factors, improve neurological deficits and improvethe ability of daily living.
      【Key words】 Acute cerebral infarction; Fluvastatin; Butylphthalide; Neurological function; Ability of daily liv-ing; Efficacy·论 著·doi:10.3969/j.issn.1003-6350.2018.22.008基金项目：陕西省咸阳市科学技术研究计划项目(编号：2017K02-98)