标题：注射用七叶皂苷钠对猕猴颅内压的影响

      作者：张 睿 1，庾俊雄 1*，邱维加 2，周智鹏 2，邓燕贤 2
    （桂林医学院附属医院麻醉科 1、放射科 2，广西 桂林 541001）

      卷次： 2012年23卷7期

      【摘要】 目的 在灵长类动物水平，观察注射用七叶皂苷钠在制备脑栓塞模型过程中各项生命体征的变
化，进而探讨注射用七叶皂苷钠对颅内压的影响。方法 本实验将健康雄性猕猴12只随机分为实验组和对照
组，在制作脑栓塞模型过程中，实验组给予七叶皂苷钠（0.4 mg/kg），对照组给予同等量的生理盐水。实验组和对
照组分别在栓塞前、栓塞后记录各项生命体征变化。结果 实验组猕猴在栓塞后，动脉收缩压和动脉舒张压较
对照组低（P<0.05）；心率和呼吸频率较对照组比较差异无统计学意义（P>0.05）。对照组栓塞后，动脉收缩压、动
脉舒张压和心率较栓塞前显著升高（P<0.05），呼吸频率较栓塞前下降显著（P<0.05）。结论 注射用七叶皂苷钠
可维持脑栓塞过程中生命体征的平稳，在一定程度上可以降低由于脑栓塞引发的急性颅内压升高。

      【关键词】 七叶皂苷钠；脑栓塞；颅内压

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2012）07—018—03<

br>Effect of sodium aescinate on the intracranial pressure in monkey.
ZHANG Rui 1, YU Jun-xiong 1*, QIU Wei-jia 2,
ZHOU Zhi-peng 2, DENG Yan-xian 2. Department of Anesthesiology 1, Department of Radiology 2, the Affiliated Hospital
of Guilin Medical College, Guilin 541001, Guangxi, CHINA

【Abstract】 Objective To observe the vital signs in the preparation of cerebral embolism model process us-
ing sodium aescinate at the level of primates, and then discuss the effect of sodium aescinate on the intracranial pres-
sure. Methods Twelve healthy male macaques were randomly divided into the study group and the control group,
each with 6 cases. In the production process of cerebral embolism model, the study group was given 0.4 mg/kg sodium
aescinate, while the control group was given the same amount of saline. The vital signs were recorded before emboliza-
tion and after embolization in the two groups. Results After embolization, the artery systolic blood pressure and dia-
stolic blood pressure in the study group were significantly lower than those in the control group (P<0.05), while heart
rate and breathing rate showed no statistically significant difference with those in the control group (P>0.05). In the control
group, the artery systolic blood pressure, diastolic blood pressure and heart rate after embolization increased significantly, com-
pared with whose before embolization (P<0.05), while the breathing rate decreased significantly (P<0.05). Conclusion Sodi-
um aescinate can maintain the smooth vital signs in process of cerebral embolism, and, to some extent, can reduce the
intracranial pressure caused by cerebral embolism.

      【Key words】 Sodium aescinate; Cerebral embolism; Intracranial pressure
基金项目：国家自然科学基金（编号：30860293；81160147）