标题：十堰市胃食管反流病患病情况及影响因素

      作者：张敏 1，王斌 2，周春芳 2，黄小明 3    (1.十堰市人民医院白浪分院消化内科，湖北 十堰 442000；2.十堰市人民医院消化内科，湖北 十堰 442000；3.西南医科大学公共卫生学院营养与食品卫生学教研室，四川 泸州 646000)

      卷次： 2018年29卷20期

      【摘要】 目的 调查十堰市成人胃食管反流病(GERD)患病情况，分析GERD发病的影响因素。方法 于2017年1~12月随机抽取十堰市18岁以上居民3 352人，用胃食管反流病量表(Gerd Q)结合质子泵抑制剂(PPI)试验调查GERD患病率，再用病例对照研究方法分析GERD发病的影响因素。结果 (1) Gerd Q得分≥8分者137例，发生率为4.1%，确诊GERD患者107例，GERD确诊率为3.2%；(2)采用χ2检验进行单因素分析发现，年龄、性别、体质指数、喜油腻、吸烟和Hp感染是GERD的危险因素(P<0.05)；(3)多因素Logistic回归显示：性别女性(OR=2.101，95%CI=1.697~2.944)、体质指数≥24 (OR=2.920，95%CI=2.105~3.852)、喜油腻(OR=1.794，95%CI=1.237~2.731)和吸烟(OR=2.071，95%CI=1.560~2.869)是GERD的危险因素(P<0.05)。结论 十堰市成人GERD患病率略低于全国水平，性别、肥胖、喜油腻和吸烟可能是GERD发病的危险因素，应加强健康教育，促进行为生活方式的改变，从而预防GERD的发生。
      【关键词】 十堰市；胃食管反流病；患病率；危险因素
      【中图分类号】 R572 【文献标识码】 D 【文章编号】 1003—6350（2018）20—2917—04

Investigation on the prevalence and influencing factors of gastroesophageal reflux disease in Shiyan City.
ZHANGMin 1, WANG Bin 2, ZHOU Chun-fang 2, HUANG Xiao-ming 3. 1. Department of Gastroenterology, Bailang Branch ofShiyan People’s Hospital, Shiyan 442000, Hubei, CHINA; 2. Department of Gastroenterology, Shiyan People's Hospital,Shiyan 442000, Hubei, CHINA; 3. Department of Nutrition and Food Hygiene, Southwest Medical University, Luzhou646000, Sichuan, CHINA
【Abstract】 Objective To investigate the prevalence of gastroesophageal reflux disease (GERD) in ShiyanCity, and explore the influencing factors of GERD. Methods From January 2017 to December 2017, 3 352 residentsover 18 years old were selected randomly from Shiyan City to investigate the prevalence of GERD by gastroesophagealreflux disease questionnaire (Gerd Q) combining with proton pump inhibitor (PPI) test, and the influencing factors ofGERD were explored by case-control study. Results (1) There were 137 cases of Gerd Q score ≥ 8 with the preva-lence of 4.1%, and 107 cases were definitely diagnosed with GERD with the prevalence of 3.2%. (2) Univariate analysisshowed that age, gender, body mass index (BMI), preference of greasy food, smoking and Helicobacter pylori (Hp) werethe risk factors of GERD by Chi-square test (P<0.05). (3) Multiple factors logistic regression analysis indicated that fe-male (OR=2.101, 95% CI=1.697 to 2.944), BMI≥24 (OR=2.920, 95% CI=2.105 to 3.852), preference of greasy food(OR=1.794, 95%CI=1.237 to 2.731) and smoking (OR=2.071, 95%CI=1.560 to 2.869) were the risk factors of GERD(P<0.05). Conclusion The prevalence of GERD in Shiyan City is slightly lower than national average. Gender, over-weight, preference of greasy food and smoking are probable risk factors of GERD. It is essential to strengthen health edu-cation and promote behaviors and lifestyle changes for preventing GERD.
      【Key words】 Shiyan City; Gastroesophageal reflux disease (GERD); Prevalence; Risk factors·调查研究·doi:10.3969/j.issn.1003-6350.2018.20.033基金项目：湖北省十堰市科技局市级科学技术研究与开发专项基金项目(编号：16K70)