标题：Ala-Gln胃肠外营养治疗中度烧伤患者临床疗效观察

      作者：李鸿明，周金武，沈光裕，陈建设，李泰昌
    (中国人民解放军第一八七医院烧伤整形科，海南 海口 571159)

      卷次： 2012年23卷1期

      【摘要】 目的 了解丙氨酰谷氨酰胺（Ala-Gln）外营养治疗中度烧伤成人患者的临床意义。方法 将2010
年4月至2011年6月入院的中度烧伤患者随机分为治疗组和对照组（准入条件：均为中Ⅱ°烧伤成人），治疗组给
予5%复方氨基酸500 ml+Ala-Gln 20 g静滴，1次/d，对照组给予5%复方氨基酸500 ml静滴，1次/d。创面均给予
保痂治疗，每日清创一次，均给予静脉输注抗生素，2次/d，观察患者血常规、肝功能（ALT）变化转归及创面愈合时
间。结果 治疗组、对照组血常规、ALT比较差异无统计学意义，治疗组浅Ⅱ°创面愈合时间7~10 d，深Ⅱ°创面愈
合时间 18~24 d，对照组浅Ⅱ°创面愈合时间 9~16 d，深Ⅱ°创面愈合时间 19~32 d，两组比较差异有统计学意义。
结论 中度烧伤成人患者给予Ala-Gln静脉输注可显著促进创面愈合，缩短住院时间，节约住院费用，具有显著
临床应用价值。

      【关键词】 丙氨酰谷氨酰胺；中度烧伤；临床疗效

      【中图分类号】 R644 【文献标识码】 A 【文章编号】 1003—6350（2012）01—061—02<

br>Clinical effect of Alanyl-Glutamine supplemented total parenteral nutrition (TPN) for the treatment of
moderate burn in adults.
LI Hong-ming, ZHOU Jin-wu, SHEN Guang-yu, CHEN Jian-she, LI Tai-chang.
Department of Burn and Plastic Surgery, the 187th Hospital of PLA, Haikou 271159, Hainan, CHINA

【Abstract】 Objective To explore the clinical effect of Alanyl-Glutamine (Ala-Gln) supplemented total
parenteral nutrition (TPN) in the treatment of moderate burn in adults. Methods 371 adult patients with moder-
ate burn admitted from April 2010 to July 2011 in our hospital were randomly divided into the study group (n=
190) and the control group (n=181). Patients in the study group received injection of 500 ml 5% compound amino
acid and 20 g Ala-Gln once a day, while those in the control group were treated with injection of 500 ml 5% com-
pound amino acid once a day. All burn wounds were cleansed every day, and were treated by eschar reservation as
well as intravenous infusion of antibiotics twice a day. Routine blood test, serum ALT and wound healing time
were investigated. Results Routine blood test and serum ALT showed no statistically significant different between
the study group and the control group. Wound healing time in the study group were 7~10 days for superficial second
degree burn wounds and 18~24 days for deep second degree burn wounds, which showed statistically significant dif-
ference with those in the control group, 9~16 days and 19~32 days respectively. Conclusion For moderate burn in
adults, Ala-Gln supplemented TPN can promote wound healing, shorten length of hospital stay and economize the hos-
pitalization costs, which is of great clinical value.

      【Key words】 Alanyl-Glutamine (Ala-Gln); Moderate burn; Clinical effect
作者简介:李鸿明（1975—），男，新疆乌鲁木齐市人，主治医师，硕士。